Local descriptors of protein structure
We have introduced the concept of local descriptors of protein structure to characterize local neighborhoods of amino acids in proteins including short- and long-range interactions. We have build a library of recurring local descriptors and show that this library is general enough to allow assembly of unseen protein structures. Thus the method identifies, in a systematic way, the local building blocks that are common to many proteins with otherwise unrelated global structures (folds). The descriptor building block approach has many possible applications and we have applied them to prediction of protein-ligand interactions, fold recognition, residue-residue contact prediction and prediction of function from structure.
Presentation at Stockholm Bioinformatics Centre, 2009.
Articles using local descriptors
Theses using local descriptors