Table 10 Uncharacterized genes with classifications that match

biological functions deduced from homology information

This table shows the 11 out of 24 uncharacterized genes where homology information could be found that allowed assumptions concerning functional classification of the gene, and where one or more of the homology-based annotations matched the predicted (classified) biological process function.

Symbol (Accession number)	Gene name	Homology information	Classification	Classification matching assumed biological process (PMID reference)
LOC55977 (AA037007)	hypothetical protein 24636	H.sapiens thromboxane A-2 receptor, 53%/55 aa	protein metabolism and modification, lipid metabolism, developmental processes, blood coagulation	developmental processes (10963722)  blood coagulation (8777579)
FLJ10217 (W721889)	oxysterol-binding protein-related protein 1	H.sapiens oxysterol-binding protein,36% / 711 aa	cell death, blood coagulation	cell death (10617772) blood coagulation (10617772)
WW45 (H25014)	WW Domain-Containing Gene	WW domain	cell surface receptor linked signal transduction, transcription	transcription (11223034)
PIST (N68337)	PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10	M.musculus syntrophin, 43% / 110 aa	stress response, protein metabolism and modification, cell surface receptor linked signal transduction, transcription	stress response (10212242, 10797403)
ESTs (N33510)	ESTs, Weakly similar to A Chain A, Human Cd69 - Trigonal Form {SUB 82-199 [H.sapiens]	H.sapiens cd69, 52% / 37 aa	cell surface receptor linked signal transduction, cell cycle, transcription	cell surface receptor linked signal transduction (11092246)
PTGFRN (AA045111)	prostaglandin F2 receptor negative regulator	ortholog of R.norvegicus prostaglandin F2 receptor negative regulator http://www.ncbi.nlm.nih.gov/ HomoloGene/homol.cgi	transcription, oncogenesis	oncogenesis (11090944 )
H-l(3)mbt-l (AA026761)	H-l(3)mbt-like protein	D.melanogaster T13797 tumor supressor protein, 46% / 176 aa	cell proliferation, lipid metabolism, transcription, oncogenesis	cell proliferation, oncogenesis (10445843)
LOC57018 (AA016305)	cyclin L ania-6a	H.sapiens cyclin K, 27% / 363 aa	cell proliferation, transcription, oncogenesis	cell proliferation, transcription (9632813)
CNAP1 (N89934)	chromosome condensation-related SMC-associated protein 1	*	cell surface receptor linked signal transduction, cell cycle, transcription	cell cycle (11136719)
HMGE (AA037156)	GrpE-like protein cochaperone	E.coli heat shock protein grpE, 32% / 178 aa	stress response, protein metabolism and modification	stress response, protein metabolism and modification (10791710)
G2 (R16047)	G2 protein	H.sapiens G01449 probable mucin, 100% / 1691 aa	cell adhesion, cell cycle, DNA metabolism, protein targeting	cell adhesion (1412714)
(H72723)	ESTs, Highly similar to SMHU1B metallothionein 1B [H.sapiens]	H.sapiens SMHU1B metallothionein 1B, 98% / 60 aa	stress response, protein metabolism and modification, ion homeostasis	stress response, ion homeostasis (10801901)
RCL (W88650)	putative c-Myc-responsive	*	cell proliferation, protein metabolism and modification, intracellular signalling cascade, defense (immune) response	cell proliferation (9271375)

*No information on function or homology available in Unigene, Locus Link or GeneCards. The information for these genes was regarded too uncertain to be categorized as "known genes" during the annotation process.