Binding site rules

LYS14(1) AND mRRPE(1) AND PAC(1) => SimExpr(YGR280C) OR SimExpr(other) : 6 2

EXPR: (0.190) LYS14 (P < 0.000) mRRPE (P < 0.000) PAC (P < 0.003)

ORF SYMBOL P F C TF
YJR070C NO SYMBOL GAT3, YAP5
YHR052W CIC1 protein catabolism ->
macromolecule catabolism, protein metabolism protein binding\, bridging ->
protein binding\, bridging nucleolus, proteasome complex (sensu Eukarya) ->
nucleus, cytoplasm HAP4, MATa1
YGL099W LSG1 conjugation with cellular fusion, sporulation (sensu Saccharomyces), ribosome nucleus export ->
conjugation with cellular fusion, sporulation (sensu Fungi), cytoplasm organization and biogenesis, intracellular transport, protein metabolism, protein transport GTPase activity ->
purine nucleotide binding, hydrolase activity\, acting on acid anhydrides cytoplasm ->
cytoplasm PHO4
YGR280C PXR1 35S primary transcript processing, snRNA processing ->
cytoplasm organization and biogenesis, RNA metabolism, transcription RNA binding ->
RNA binding nucleolus ->
nucleus
YML093W UTP14 processing of 20S pre-rRNA ->
cytoplasm organization and biogenesis, RNA metabolism, transcription snoRNA binding ->
RNA binding small nucleolar ribonucleoprotein complex ->
nucleus, ribonucleoprotein complex
YNL110C NOP15 ribosomal large subunit biogenesis ->
cytoplasm organization and biogenesis nucleus, nucleolus ->
nucleus
|YMR290C| HAS1 nucleolus, nuclear membrane ->
nucleus, endomembrane system RAP1
|YMR259C| NO SYMBOL ARG80, GCR2, GTS1, HIR1, SRD1
Main: cytoplasm organization and biogenesis (0.80) RNA binding (0.50) nucleus (0.83) GCR2 (0.20)
Score: 0.70 0.17 0.73 0.000
P-value: 3.295E-03 (ribosome biogenesis) 6.494E-01 (RNA binding) 3.761E-05 (nucleolus) 9.470E-01 (MATa1)

CSRE(1) AND ALPHA1(1) AND STRE(1) => SimExpr(YKL085W) OR SimExpr(other) : 5 1

EXPR: (0.199) STRE (P < 0.005) CSRE (P < 0.000) ALPHA1 (P < 0.000)

ORF SYMBOL P F C TF
|YGL062W| PYC1 NADPH regeneration, gluconeogenesis ->
coenzymes and prosthetic group metabolism, alcohol metabolism, carbohydrate metabolism, vitamin metabolism, biosynthesis, energy pathways pyruvate carboxylase activity ->
pyruvate carboxylase activity cytosol ->
cytoplasm DIG1, GCR1, STE12
YKL085W MDH1 tricarboxylic acid cycle, malate metabolism ->
carbohydrate metabolism, organic acid metabolism, energy pathways L-malate dehydrogenase activity ->
L-malate dehydrogenase activity mitochondrial matrix ->
cytoplasm IME4, MTH1, RTG1, YJL206C
YIL052C RPL34B protein biosynthesis ->
biosynthesis, protein metabolism structural constituent of ribosome ->
structural constituent of ribosome cytosolic large ribosomal subunit (sensu Eukarya) ->
cytoplasm, ribonucleoprotein complex RME1
YNL098C RAS2 pseudohyphal growth, sporulation (sensu Saccharomyces), adenylate cyclase activation, RAS protein signal transduction ->
cell organization and biogenesis, sporulation, signal transduction RAS small monomeric GTPase activity ->
RAS small monomeric GTPase activity plasma membrane ->
plasma membrane ACE2, SKN7
YMR291W NO SYMBOL RAP1
YDR276C PMP3 cation transport ->
transport plasma membrane ->
plasma membrane GAT1
Main: energy pathways (0.40) pyruvate carboxylase activity (0.25) cytoplasm (0.60) RTG1 (0.17)
Score: 0.20 0.00 0.40 0.000
P-value: 8.572E-02 (main pathways of carbohydrate metabolism) 2.077E+00 (enzyme activity) 4.197E-01 (plasma membrane) 5.170E-01 (GAT1)

RAP1(1) AND MCM1'(1) => SimExpr(YOL120C) OR SimExpr(other) : 18 2

EXPR: (0.127) MCM1' (P < 0.000) RAP1 (P < 0.000)

RAP1(1) AND mRRPE(1) => SimExpr(YOL120C) OR SimExpr(other) : 7 3

EXPR: (0.160) mRRPE (P < 0.000) RAP1 (P < 0.108)

RAP1(1) AND SWI5(1) AND MCM1'(1) => SimExpr(YOL120C) OR SimExpr(other) : 6 1

EXPR: (0.121) SWI5 (P < 0.000) MCM1' (P < 0.000) RAP1 (P < 0.030)

ORF SYMBOL P F C TF
YKL006W RPL14A protein biosynthesis ->
protein biosynthesis RNA binding, structural constituent of ribosome ->
RNA binding, structural constituent of ribosome cytosolic large ribosomal subunit (sensu Eukarya) ->
cytosolic ribosome (sensu Eukarya), large ribosomal subunit FHL1, GAT3, GRF10(Pho2), GTS1, RAP1
|YLR452C| SST2 signal transduction, adaptation to pheromone during conjugation with cellular fusion ->
signal transduction, adaptation to pheromone during conjugation with cellular fusion GTPase activator activity ->
GTPase activator activity plasma membrane ->
plasma membrane DIG1, FHL1, RAP1, STE12
YNL069C RPL16B protein biosynthesis ->
protein biosynthesis RNA binding, structural constituent of ribosome ->
RNA binding, structural constituent of ribosome cytosolic large ribosomal subunit (sensu Eukarya) ->
cytosolic ribosome (sensu Eukarya), large ribosomal subunit FHL1, GAT3, PDR1, RAP1, RGM1, YAP5
YGL030W RPL30 protein biosynthesis, rRNA processing, mRNA splicing, regulation of translation ->
protein biosynthesis, rRNA processing, mRNA splicing, regulation of translation structural constituent of ribosome ->
structural constituent of ribosome cytosolic large ribosomal subunit (sensu Eukarya), cytoplasm ->
cytosolic ribosome (sensu Eukarya), cytoplasm, large ribosomal subunit FHL1, GAT3, RAP1, SFP1
YOL120C RPL18A protein biosynthesis ->
protein biosynthesis structural constituent of ribosome ->
structural constituent of ribosome cytosolic large ribosomal subunit (sensu Eukarya) ->
cytosolic ribosome (sensu Eukarya), large ribosomal subunit FHL1, MAL13, RAP1, YAP5
YDR450W RPS18A protein biosynthesis ->
protein biosynthesis structural constituent of ribosome ->
structural constituent of ribosome cytosolic small ribosomal subunit (sensu Eukarya) ->
cytosolic ribosome (sensu Eukarya), eukaryotic 43S pre-initiation complex, eukaryotic 48S initiation complex, small ribosomal subunit FHL1, GAT3, HIR2, RAP1, RGM1, YAP5
YLR344W RPL26A protein biosynthesis ->
protein biosynthesis RNA binding, structural constituent of ribosome ->
RNA binding, structural constituent of ribosome cytosolic large ribosomal subunit (sensu Eukarya) ->
cytosolic ribosome (sensu Eukarya), large ribosomal subunit FHL1, RAP1
Main: protein biosynthesis (0.86) structural constituent of ribosome (0.86) cytosolic ribosome (sensu Eukarya) (0.86) RAP1 FHL1 (1.00)
Score: 0.71 0.71 0.71 1.000
P-value: 1.319E-04 (protein biosynthesis) 2.360E-06 (structural constituent of ribosome) 5.663E-07 (cytosolic ribosome (sensu Eukarya)) 2.380E-10 (FHL1)

RAP1(1) AND ALPHA1'(1) AND MCM1'(1) => SimExpr(YOL120C) : 7

EXPR: (0.112) ALPHA1' (P < 0.000) MCM1' (P < 0.000) RAP1 (P < 0.022)

CSRE(1) AND HAP234(1) => SimExpr(YOR136W) OR SimExpr(other) : 5 1

EXPR: (0.172) CSRE (P < 0.000) HAP234 (P < 0.007)

ORF SYMBOL P F C TF
|YKL141W| SDH3 oxidative phosphorylation\, succinate to ubiquinone, tricarboxylic acid cycle ->
electron transport, carbohydrate metabolism, phosphorus metabolism, energy pathways succinate dehydrogenase activity ->
succinate dehydrogenase activity respiratory chain complex II (sensu Eukarya) ->
cytoplasm, respiratory chain complex II, succinate dehydrogenase complex (ubiquinone), inner membrane
YPR145W ASN1 asparagine biosynthesis ->
amine metabolism, amino acid and derivative metabolism, organic acid metabolism, biosynthesis asparagine synthase (glutamine-hydrolyzing) activity ->
asparagine synthase (glutamine-hydrolyzing) activity DAL81, GCN4, GLN3, MET4, RAP1, SUM1
YLR304C ACO1 tricarboxylic acid cycle, citrate metabolism, glutamate biosynthesis, propionate metabolism ->
carbohydrate metabolism, amine metabolism, organic acid metabolism, energy pathways, amino acid and derivative metabolism, biosynthesis aconitate hydratase activity ->
aconitate hydratase activity cytosol, mitochondrial matrix ->
cytoplasm CIN5, YAP6
YNL069C RPL16B protein biosynthesis ->
biosynthesis, protein metabolism RNA binding, structural constituent of ribosome ->
RNA binding, structural constituent of ribosome cytosolic large ribosomal subunit (sensu Eukarya) ->
cytoplasm, ribonucleoprotein complex FHL1, GAT3, PDR1, RAP1, RGM1, YAP5
YOR136W IDH2 tricarboxylic acid cycle, isocitrate metabolism, glutamate biosynthesis ->
carbohydrate metabolism, amine metabolism, organic acid metabolism, energy pathways, amino acid and derivative metabolism, biosynthesis isocitrate dehydrogenase (NAD+) activity ->
isocitrate dehydrogenase (NAD+) activity mitochondrial matrix, mitochondrion ->
cytoplasm MET4
YFR033C QCR6 aerobic respiration, oxidative phosphorylation\, ubiquinone to cytochrome c ->
energy pathways, electron transport, phosphorus metabolism ubiquinol-cytochrome c reductase activity ->
ubiquinol-cytochrome c reductase activity mitochondrion, respiratory chain complex III (sensu Eukarya) ->
cytoplasm, respiratory chain complex III, inner membrane HAP4, MBP1
Main: biosynthesis (0.67) RNA binding (0.17) cytoplasm (1.00) RAP1 MET4 (0.40)
Score: 0.73 0.00 1.00 0.200
P-value: 4.809E-05 (tricarboxylic acid cycle) 3.006E-02 (oxidoreductase activity) 7.682E-03 (mitochondrial electron transport chain) 5.318E-02 (MET4)

RAP1(1) AND MCM1'(1) => SimExpr(YGR254W) OR SimExpr(other) : 18 2

RAP1(1) AND ALPHA1(1) AND SFF(1) => SimExpr(YGR254W) OR SimExpr(other) : 14 3

EXPR: (0.232) SFF (P < 0.000) RAP1 (P < 0.038) ALPHA1 (P < 0.000)

RAP1(1) AND ALPHA1(1) AND SFF'(1) => SimExpr(YGR254W) OR SimExpr(other) : 14 4

EXPR: (0.237) SFF' (P < 0.000) RAP1 (P < 0.072) ALPHA1 (P < 0.000)

RAP1(1) AND ALPHA1(1) AND MCM1'(1) => SimExpr(YGR254W) : 9

EXPR: (0.189) MCM1' (P < 0.000) RAP1 (P < 0.005) ALPHA1 (P < 0.000)

CSRE(1) AND RAP1(1) AND MCM1'(1) => SimExpr(YGR254W) : 9

EXPR: (0.191) MCM1' (P < 0.000) CSRE (P < 0.000) RAP1 (P < 0.002)

RAP1(1) AND ALPHA1'(1) AND MCM1'(1) => SimExpr(YGR254W) : 7

REB1(1) AND ALPHA2(1) AND SWI5(1) => SimExpr(YOR025W) : 5

EXPR: (0.181) ALPHA2 (P < 0.000) SWI5 (P < 0.000) REB1 (P < 0.000)

ORF SYMBOL P F C TF
YOR152C NO SYMBOL HIR2
YNL197C WHI3 regulation of cell size ->
cell organization and biogenesis RNA binding ->
RNA binding REB1
YNL111C CYB5 sterol biosynthesis ->
alcohol metabolism, biosynthesis, lipid metabolism electron transporter activity ->
electron transporter activity microsome ->
microsome ABF1, GCR2, GTS1, NRG1, REB1, ROX1
YNL090W RHO2 microtubule-based process, cell wall organization and biogenesis, small GTPase mediated signal transduction, establishment of cell polarity (sensu Saccharomyces), actin filament organization ->
signal transduction, cell organization and biogenesis, organelle organization and biogenesis Rho small monomeric GTPase activity, signal transducer activity ->
Rho small monomeric GTPase activity, signal transducer activity intracellular ->
intracellular INO4, REB1
YOR025W HST3 chromatin silencing at telomere, short-chain fatty acid metabolism ->
cell organization and biogenesis, lipid metabolism, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, transcription, organic acid metabolism DNA binding ->
DNA binding intracellular ->
intracellular IXR1, NDD1
Main: cell organization and biogenesis (0.75) DNA binding (0.25) intracellular (0.67) REB1 (0.60)
Score: 0.67 0.00 0.33 0.300
P-value: 1.465E-01 (lipid metabolism) 7.055E-01 (binding) 3.995E+00 (intracellular) 5.118E-03 (REB1)

CSRE(1) AND HAP234(1) => SimExpr(YLR304C) : 6

CSRE(1) AND PDR(1) AND ATRepeat(1) => SimExpr(YLR304C) : 5

EXPR: (0.171) PDR (P < 0.003) ATRepeat (P < 0.000) CSRE (P < 0.000)

ORF SYMBOL P F C TF
YGL062W PYC1 NADPH regeneration, gluconeogenesis ->
coenzymes and prosthetic group metabolism, alcohol metabolism, carbohydrate metabolism, vitamin metabolism, biosynthesis, energy pathways pyruvate carboxylase activity ->
pyruvate carboxylase activity cytosol ->
cytoplasm DIG1, GCR1, STE12
YKL141W SDH3 oxidative phosphorylation\, succinate to ubiquinone, tricarboxylic acid cycle ->
electron transport, carbohydrate metabolism, phosphorus metabolism, energy pathways succinate dehydrogenase activity ->
succinate dehydrogenase activity respiratory chain complex II (sensu Eukarya) ->
cytoplasm, respiratory chain complex II, succinate dehydrogenase complex (ubiquinone), inner membrane
YLR304C ACO1 tricarboxylic acid cycle, citrate metabolism, glutamate biosynthesis, propionate metabolism ->
carbohydrate metabolism, amine metabolism, organic acid metabolism, energy pathways, amino acid and derivative metabolism, biosynthesis aconitate hydratase activity ->
aconitate hydratase activity cytosol, mitochondrial matrix ->
cytoplasm CIN5, YAP6
YOR153W PDR5 drug transport, response to drug ->
transport, response to abiotic stimulus xenobiotic-transporting ATPase activity ->
xenobiotic-transporting ATPase activity plasma membrane ->
plasma membrane YAP6
YNL231C PDR16 phospholipid transport, sterol biosynthesis, response to drug ->
transport, alcohol metabolism, response to abiotic stimulus, biosynthesis, lipid metabolism phosphatidylinositol transporter activity ->
phosphatidylinositol transporter activity cytoplasm ->
cytoplasm HSF1, MBP1, SWI4, YAP1
Main: biosynthesis (0.60) pyruvate carboxylase activity (0.20) cytoplasm (0.80) YAP6 (0.50)
Score: 0.60 0.00 0.60 0.167
P-value: 2.167E-03 (main pathways of carbohydrate metabolism) 5.353E-01 (transporter activity) 7.999E-01 (cytosol) 1.030E-01 (YAP6)

CSRE(1) AND RAP1(1) => SimExpr(YML073C) OR SimExpr(other) : 12 2

EXPR: (0.158) CSRE (P < 0.000) RAP1 (P < 0.026)

CSRE(1) AND RAP1(1) AND MCM1'(1) => SimExpr(YML073C) : 9

RAP1(1) AND ALPHA1(1) AND MCM1'(1) => SimExpr(YML073C) : 9

CSRE(1) AND RAP1(1) => SimExpr(YGL147C) OR SimExpr(other) : 12 2

CSRE(1) AND RAP1(1) AND MCM1'(1) => SimExpr(YGL147C) : 9

CSRE(1) AND RAP1(1) => SimExpr(YJR145C) OR SimExpr(other) : 11 3

ABF1(1) AND ALPHA1'(1) AND PAC(1) => SimExpr(YPR010C) : 5

EXPR: (0.166) ABF1 (P < 0.000) ALPHA1' (P < 0.000) PAC (P < 0.000)

ORF SYMBOL P F C TF
YOL041C NOP12 rRNA metabolism ->
nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism RNA binding ->
RNA binding nucleolus ->
nucleus GTS1, MET31
YPR010C RPA135 transcription from Pol I promoter ->
nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism DNA-directed RNA polymerase activity ->
transferase activity\, transferring phosphorus-containing groups DNA-directed RNA polymerase I complex ->
nucleus ROX1, SIG1
YNL292W PUS4 tRNA modification ->
nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism pseudouridylate synthase activity ->
carbon-oxygen lyase activity mitochondrion, nucleus ->
cytoplasm, nucleus RCS1
YNL112W DBP2 RNA helicase activity ->
RNA binding bud neck ->
site of polarized growth (sensu Fungi)
YKL014C NO SYMBOL ABF1
Main: nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism (1.00) RNA binding (0.50) nucleus (0.75) ABF1 (0.25)
Score: 1.00 0.17 0.50 0.000
P-value: 2.994E-01 (RNA metabolism) 3.258E-01 (RNA binding) 9.452E-02 (nucleolus) 3.281E-01 (SIG1)

CSRE(1) AND RAP1(1) => SimExpr(YOR312C) OR SimExpr(other) : 12 2

CSRE(1) AND HAP234(1) => SimExpr(YFR033C) OR SimExpr(other) : 5 1

CSRE(1) AND ALPHA1(1) AND SFF'(1) AND CCA(1) => SimExpr(YOL082W) OR SimExpr(other) : 5 2

EXPR: (0.218) SFF' (P < 0.000) CCA (P < 0.002) CSRE (P < 0.000) ALPHA1 (P < 0.000)

ORF SYMBOL P F C TF
|YKL141W| SDH3 oxidative phosphorylation\, succinate to ubiquinone, tricarboxylic acid cycle ->
electron transport, carbohydrate metabolism, phosphorus metabolism, energy pathways succinate dehydrogenase activity ->
succinate dehydrogenase activity respiratory chain complex II (sensu Eukarya) ->
cytoplasm, respiratory chain complex II, succinate dehydrogenase complex (ubiquinone), inner membrane
YOR152C NO SYMBOL HIR2
YLR328W NMA1 nicotinamide adenine dinucleotide metabolism ->
coenzymes and prosthetic group metabolism, vitamin metabolism nicotinamide-nucleotide adenylyltransferase activity ->
nicotinamide-nucleotide adenylyltransferase activity CIN5, MSN1, ROX1
YOL082W CVT19 protein-vacuolar targeting ->
cell organization and biogenesis, protein metabolism, transport protein binding ->
protein binding vacuole, peripheral membrane protein of membrane fraction, cytoplasm ->
cytoplasm, membrane fraction GTS1, MCM1, RAP1, STE12
YMR008C PLB1 glycerophospholipid metabolism ->
lipid metabolism lysophospholipase activity ->
lysophospholipase activity cell wall (sensu Fungi) ->
cell wall RAP1
|YLR406C| RPL31B protein biosynthesis ->
biosynthesis, protein metabolism structural constituent of ribosome ->
structural constituent of ribosome cytosolic large ribosomal subunit (sensu Eukarya) ->
cytoplasm, ribonucleoprotein complex FHL1, FKH1, MTH1, RAP1
YKR003W OSH6 steroid biosynthesis ->
biosynthesis, lipid metabolism oxysterol binding ->
oxysterol binding
Main: biosynthesis (0.33) nicotinamide-nucleotide adenylyltransferase activity (0.17) cytoplasm (0.75) RAP1 (0.60)
Score: 0.20 0.00 0.50 0.300
P-value: 2.539E-01 (lipid metabolism) 2.769E+00 (binding) 4.385E+00 (cytoplasm) 7.002E-02 (RAP1)

RAP1(1) AND MCM1'(1) => SimExpr(YPL090C) OR SimExpr(other) : 19 1

CSRE(1) AND RAP1(1) => SimExpr(YPL090C) OR SimExpr(other) : 12 2

CSRE(1) AND RAP1(1) AND MCM1'(1) => SimExpr(YPL090C) : 9

RAP1(1) AND ALPHA1'(1) AND MCM1'(1) => SimExpr(YPL090C) : 7

CSRE(1) AND GCN4(1) => SimExpr(YPR145W) OR SimExpr(other) : 5 2

EXPR: (0.223) GCN4 (P < 0.030) CSRE (P < 0.022)

ORF SYMBOL P F C TF
|YGL184C| STR3 methionine biosynthesis ->
amine metabolism, sulfur metabolism, biosynthesis, amino acid and derivative metabolism, organic acid metabolism cystathionine beta-lyase activity ->
cystathionine beta-lyase activity peroxisome ->
cytoplasm INO4, MET31, MET4
|YNL019C| NO SYMBOL
YLR355C ILV5 branched chain family amino acid biosynthesis, mitochondrial genome maintenance ->
amine metabolism, cell organization and biogenesis, amino acid and derivative metabolism, organic acid metabolism, biosynthesis ketol-acid reductoisomerase activity ->
ketol-acid reductoisomerase activity mitochondrion ->
cytoplasm GCN4, MET4
YPR145W ASN1 asparagine biosynthesis ->
amine metabolism, amino acid and derivative metabolism, organic acid metabolism, biosynthesis asparagine synthase (glutamine-hydrolyzing) activity ->
asparagine synthase (glutamine-hydrolyzing) activity DAL81, GCN4, GLN3, MET4, RAP1, SUM1
YGL207W SPT16 chromatin modeling, regulation of global transcription from Pol II promoter, RNA elongation from Pol II promoter ->
cell organization and biogenesis, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, DNA metabolism transcriptional elongation regulator activity ->
transcriptional elongation regulator activity alpha DNA polymerase\:primase complex, nuclear chromatin, transcription elongation factor complex ->
nucleus, chromosome RTG1
YNL098C RAS2 pseudohyphal growth, sporulation (sensu Saccharomyces), adenylate cyclase activation, RAS protein signal transduction ->
cell organization and biogenesis, sporulation, signal transduction RAS small monomeric GTPase activity ->
RAS small monomeric GTPase activity plasma membrane ->
plasma membrane ACE2, SKN7
YOL092W NO SYMBOL MAC1
Main: cell organization and biogenesis (0.60) RAS small monomeric GTPase activity (0.20) cytoplasm (0.50) MET4 (0.50)
Score: 0.60 0.00 0.17 0.200
P-value: 1.165E-02 (amino acid biosynthesis) 1.628E+00 (enzyme activity) 4.869E+00 (cytoplasm) 1.489E-03 (MET4)

CSRE(1) AND HAP234(1) => SimExpr(YPR145W) : 6

CSRE(1) AND MCB(1) => SimExpr(YMR076C) OR SimExpr(other) : 5 2

EXPR: (0.191) MCB (P < 0.121) CSRE (P < 0.000)

ORF SYMBOL P F C TF
YDR309C GIC2 axial budding, Rho protein signal transduction, establishment of cell polarity (sensu Saccharomyces) ->
axial budding, small GTPase mediated signal transduction, organelle organization and biogenesis small GTPase regulatory/interacting protein activity ->
small GTPase regulatory/interacting protein activity actin cap (sensu Saccharomyces), bud tip, shmoo tip, incipient bud site ->
cell cortex, site of polarized growth (sensu Fungi), incipient bud site, cytoplasm ASH1, HSF1, MBP1, PHD1, RLM1, SKN7, STB1, STE12, SWI4, SWI6
|YJR006W| HYS2 leading strand elongation, lagging strand elongation, mutagenesis, base-excision repair, nucleotide-excision repair, postreplication repair, mismatch repair ->
mutagenesis, DNA repair, postreplication repair, DNA replication and chromosome cycle, mitotic cell cycle, DNA metabolism delta DNA polymerase activity ->
delta DNA polymerase activity delta DNA polymerase complex ->
cytoplasm, nucleus ABF1
YML027W YOX1 negative regulation of transcription from Pol II promoter\, mitotic, regulation of mitotic cell cycle ->
mitotic cell cycle, M phase, regulation of transcription, nuclear division, transcription\, DNA-dependent, regulation of cell cycle specific transcriptional repressor activity, DNA binding ->
specific transcriptional repressor activity, DNA binding nucleus ->
nucleus MBP1, SWI4, SWI6
YDR134C NO SYMBOL ASH1, NRG1, SOK2, SWI4
|YMR279C| NO SYMBOL IXR1, MIG1, MTH1, RFX1, SWI4, SWI6
YMR076C PDS5 mitotic sister chromatid cohesion, mitotic chromosome condensation ->
DNA replication and chromosome cycle, M phase, mitotic cell cycle structural molecule activity ->
structural molecule activity condensed nuclear chromosome ->
chromosome, nucleus FKH2, MBP1, SWI6
YHR110W ERP5 secretory pathway ->
secretory pathway integral to membrane ->
integral to membrane DOT6, RGT1
Main: mitotic cell cycle (0.60) DNA binding (0.25) nucleus (0.60) SWI4 SWI6 (0.57)
Score: 0.30 0.00 0.40 0.429
P-value: 1.664E-01 (mitotic cell cycle) 2.000E+00 2.837E+00 (nucleus) 5.504E-04 (SWI6)

ALPHA1(1) AND MCB(1) => SimExpr(YMR076C) OR SimExpr(other) : 22 10

EXPR: (0.203) MCB (P < 0.055) ALPHA1 (P < 0.000)

CSRE(1) AND ALPHA1(1) AND SFF'(1) AND CCA(1) => SimExpr(YMR008C) OR SimExpr(other) : 5 2

mRRPE(1) AND Leu3(1) => SimExpr(YLR355C) OR SimExpr(other) : 5 1

EXPR: (0.179) mRRPE (P < 0.004) Leu3 (P < 0.026)

ORF SYMBOL P F C TF
YLR355C ILV5 branched chain family amino acid biosynthesis, mitochondrial genome maintenance ->
amine metabolism, cell organization and biogenesis, amino acid and derivative metabolism, organic acid metabolism, biosynthesis ketol-acid reductoisomerase activity ->
oxidoreductase activity\, acting on the CH-OH group of donors\, NAD or NADP as acceptor mitochondrion ->
cytoplasm GCN4, MET4
YJR016C ILV3 branched chain family amino acid biosynthesis ->
amine metabolism, amino acid and derivative metabolism, organic acid metabolism, biosynthesis dihydroxy-acid dehydratase activity ->
hydro-lyase activity mitochondrion ->
cytoplasm
YKL029C MAE1 pyruvate metabolism, amino acid metabolism ->
amine metabolism, organic acid metabolism, amino acid and derivative metabolism malate dehydrogenase (oxaloacetate decarboxylating) activity ->
malate dehydrogenase activity, oxidoreductase activity\, acting on the CH-OH group of donors\, NAD or NADP as acceptor mitochondrion ->
cytoplasm ABF1, CIN5
YKR071C DRE2 CAD1, HSF1, YAP1, YAP3
YPR074C TKL1 pentose-phosphate shunt ->
coenzymes and prosthetic group metabolism, alcohol metabolism, water-soluble vitamin metabolism, carbohydrate metabolism, energy derivation by oxidation of organic compounds, catabolism transketolase activity ->
transketolase and transaldolase activity cytoplasm ->
cytoplasm REB1
|YDR043C| NRG1 response to pH, glucose metabolism, regulation of transcription from Pol II promoter, invasive growth ->
cell homeostasis, alcohol metabolism, cell organization and biogenesis, response to abiotic stimulus, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, carbohydrate metabolism transcriptional repressor activity, DNA binding ->
transcriptional repressor activity, DNA binding nucleus ->
nucleus NRG1, SKN7
Main: amino acid and derivative metabolism (0.60) oxidoreductase activity\, acting on the CH-OH group of donors\, NAD or NADP as acceptor (0.40) cytoplasm (0.80) YAP1 (0.20)
Score: 0.50 0.10 0.60 0.000
P-value: 7.579E-03 (branched chain family amino acid biosynthesis) 4.606E-02 (oxidoreductase activity\, acting on the CH-OH group of donors\, NAD or NADP as acceptor) 1.995E-01 (mitochondrion) 1.412E-01 (YAP3)

CSRE(1) AND RAP1(1) => SimExpr(YDR450W) OR SimExpr(other) : 12 2

CSRE(1) AND RAP1(1) AND MCM1'(1) => SimExpr(YDR450W) : 9

ALPHA1(1) AND PDR(1) AND ATRepeat(1) => SimExpr(YOR153W) OR SimExpr(other) : 6 2

EXPR: (0.193) PDR (P < 0.001) ATRepeat (P < 0.000) ALPHA1 (P < 0.000)

ORF SYMBOL P F C TF
|YGL062W| PYC1 NADPH regeneration, gluconeogenesis ->
coenzymes and prosthetic group metabolism, alcohol metabolism, carbohydrate metabolism, vitamin metabolism, biosynthesis, energy pathways pyruvate carboxylase activity ->
pyruvate carboxylase activity cytosol ->
cytoplasm DIG1, GCR1, STE12
YOR273C TPO4 polyamine transport ->
transport spermine transporter activity, spermidine transporter activity ->
spermine transporter activity, spermidine transporter activity plasma membrane, vacuolar membrane ->
plasma membrane, cytoplasm ARO80, BAS1, FZF1, HIR1, IME4, NRG1, PDR1, PHO4, SFP1, SKN7, STP1
YOR153W PDR5 drug transport, response to drug ->
transport, response to abiotic stimulus xenobiotic-transporting ATPase activity ->
xenobiotic-transporting ATPase activity plasma membrane ->
plasma membrane YAP6
|YGL057C| NO SYMBOL
YGL197W MDS3 sporulation ->
sporulation cytoplasm ->
cytoplasm MTH1
YKL141W SDH3 oxidative phosphorylation\, succinate to ubiquinone, tricarboxylic acid cycle ->
electron transport, carbohydrate metabolism, phosphorus metabolism, energy pathways succinate dehydrogenase activity ->
succinate dehydrogenase activity respiratory chain complex II (sensu Eukarya) ->
cytoplasm, respiratory chain complex II, succinate dehydrogenase complex (ubiquinone), inner membrane
YNL231C PDR16 phospholipid transport, sterol biosynthesis, response to drug ->
transport, alcohol metabolism, response to abiotic stimulus, biosynthesis, lipid metabolism phosphatidylinositol transporter activity ->
phosphatidylinositol transporter activity cytoplasm ->
cytoplasm HSF1, MBP1, SWI4, YAP1
YGR281W YOR1 transport, response to drug ->
transport, response to abiotic stimulus xenobiotic-transporting ATPase activity ->
xenobiotic-transporting ATPase activity plasma membrane ->
plasma membrane
Main: transport (0.57) xenobiotic-transporting ATPase activity (0.33) cytoplasm (0.71) YAP1 (0.20)
Score: 0.38 0.07 0.62 0.000
P-value: 2.468E-04 (response to drug) 4.681E-03 (xenobiotic-transporting ATPase activity) 8.119E-02 (plasma membrane) 1.000E+00

ALPHA1(1) AND MCB(1) => SimExpr(YML027W) OR SimExpr(other) : 22 10

ALPHA1(1) AND MCB(1) AND MCM1'(1) => SimExpr(YML027W) OR SimExpr(other) : 7 3

EXPR: (0.215) MCB (P < 0.253) MCM1' (P < 0.000) ALPHA1 (P < 0.000)

ORF SYMBOL P F C TF
YML027W YOX1 negative regulation of transcription from Pol II promoter\, mitotic, regulation of mitotic cell cycle ->
mitotic cell cycle, M phase, regulation of transcription, nuclear division, transcription\, DNA-dependent, regulation of cell cycle specific transcriptional repressor activity, DNA binding ->
specific transcriptional repressor activity, DNA binding nucleus ->
nucleus MBP1, SWI4, SWI6
YGR189C CRH1 cell wall, incipient bud site ->
cell wall, incipient bud site GRF10(Pho2), MBP1, RLM1, STE12, SWI4, SWI5
YGR109C CLB6 regulation of CDK activity, G1/S transition of mitotic cell cycle, premeiotic DNA synthesis ->
DNA replication and chromosome cycle, regulation of cell cycle, mitotic cell cycle, DNA metabolism cyclin-dependent protein kinase\, regulator activity ->
cyclin-dependent protein kinase\, regulator activity MBP1, STB1, SWI4, SWI6
|YMR102C| NO SYMBOL
YPR135W CTF4 DNA dependent DNA replication, DNA repair ->
DNA replication and chromosome cycle, DNA repair, mitotic cell cycle, DNA metabolism DNA binding ->
DNA binding nucleus ->
nucleus BAS1, DIG1, FZF1
|YGR085C| RPL11B protein biosynthesis, ribosomal large subunit assembly and maintenance ->
protein biosynthesis, ribosome biogenesis and assembly structural constituent of ribosome ->
structural constituent of ribosome cytosolic large ribosomal subunit (sensu Eukarya) ->
cytoplasm, ribonucleoprotein complex FHL1, MIG1
|YNR028W| CPR8 peptidyl-prolyl cis-trans isomerase activity ->
peptidyl-prolyl cis-trans isomerase activity ASH1, DIG1, MCM1
YDR134C NO SYMBOL ASH1, NRG1, SOK2, SWI4
YGL225W VRG4 nucleotide-sugar transport, N-linked glycosylation, lipid glycosylation ->
nucleotide-sugar transport, protein biosynthesis, lipid glycosylation, protein modification, glycoprotein metabolism nucleotide-sugar transporter activity ->
nucleotide-sugar transporter activity Golgi apparatus ->
cytoplasm
YNL082W PMS1 mismatch repair, meiosis ->
DNA replication and chromosome cycle, M phase, DNA repair, mitotic cell cycle, DNA metabolism ATPase activity, ATP binding, DNA binding ->
ATPase activity, ATP binding, DNA binding nuclear chromosome ->
chromosome, nucleus MTH1
Main: mitotic cell cycle (0.67) DNA binding (0.43) nucleus (0.50) SWI4 (0.50)
Score: 0.47 0.14 0.27 0.286
P-value: 5.091E-02 (DNA replication) 1.637E-01 (DNA binding) 4.464E+00 (nucleus) 9.947E-03 (SWI4)

CSRE(1) AND MCB(1) => SimExpr(YML027W) OR SimExpr(other) : 5 2

MCM1(1) AND MCB(1) => SimExpr(YML027W) OR SimExpr(other) : 7 2

EXPR: (0.191) MCB (P < 0.080) MCM1 (P < 0.000)

ORF SYMBOL P F C TF
YML027W YOX1 negative regulation of transcription from Pol II promoter\, mitotic, regulation of mitotic cell cycle ->
regulation of transcription, M phase, transcription, cell cycle specific transcriptional repressor activity, DNA binding ->
specific transcriptional repressor activity, DNA binding nucleus ->
nucleus MBP1, SWI4, SWI6
YGR189C CRH1 cell wall, incipient bud site ->
cell wall, incipient bud site GRF10(Pho2), MBP1, RLM1, STE12, SWI4, SWI5
YGL163C RAD54 double-strand break repair via synthesis-dependent strand annealing, heteroduplex formation, double-strand break repair via break-induced replication, telomerase-independent telomere maintenance, double-strand break repair via single-strand annealing, chromatin modeling ->
mating-type switching/recombination, chromosome organization and biogenesis (sensu Eukarya), DNA repair, response to DNA damage, DNA metabolism DNA supercoiling activity, DNA dependent ATPase activity ->
DNA binding, purine nucleotide binding, hydrolase activity\, acting on acid anhydrides nucleus ->
nucleus
|YIL066C| RNR3 DNA replication ->
cell cycle, DNA metabolism ribonucleoside-diphosphate reductase activity ->
oxidoreductase activity\, acting on CH2 groups cytoplasm ->
cytoplasm RFX1, STB1
YGR109C CLB6 regulation of CDK activity, G1/S transition of mitotic cell cycle, premeiotic DNA synthesis ->
cell cycle, mitotic cell cycle, DNA metabolism cyclin-dependent protein kinase\, regulator activity ->
transferase activity\, transferring phosphorus-containing groups, protein kinase regulator activity MBP1, STB1, SWI4, SWI6
YDR309C GIC2 axial budding, Rho protein signal transduction, establishment of cell polarity (sensu Saccharomyces) ->
budding, intracellular signaling cascade, cytoplasm organization and biogenesis small GTPase regulatory/interacting protein activity ->
small GTPase regulatory/interacting protein activity actin cap (sensu Saccharomyces), bud tip, shmoo tip, incipient bud site ->
cell cortex, site of polarized growth (sensu Fungi), incipient bud site, cytoplasm ASH1, HSF1, MBP1, PHD1, RLM1, SKN7, STB1, STE12, SWI4, SWI6
YKR077W NO SYMBOL
|YNR028W| CPR8 peptidyl-prolyl cis-trans isomerase activity ->
cis-trans isomerase activity ASH1, DIG1, MCM1
YDR279W RNH202 GCR2, MBP1, RIM101, RLM1, SWI6, THI2
Main: DNA metabolism (0.60) DNA binding (0.33) cytoplasm (0.40) MBP1 (0.71)
Score: 0.50 0.07 0.30 0.619
P-value: 4.056E-01 (mitotic cell cycle) 7.505E-01 (DNA binding) 5.771E-03 (incipient bud site) 5.451E-05 (MBP1)

RAP1(1) AND MCM1'(1) => SimExpr(YKL152C) OR SimExpr(other) : 18 2

CSRE(1) AND RAP1(1) => SimExpr(YKL152C) OR SimExpr(other) : 12 2

CSRE(1) AND RAP1(1) AND MCM1'(1) => SimExpr(YKL152C) : 9

RAP1(1) AND ALPHA1(1) AND MCM1'(1) => SimExpr(YKL152C) : 9

CSRE(1) AND RAP1(1) => SimExpr(YGR214W) OR SimExpr(other) : 12 2

RAP1(1) AND MCM1'(1) => SimExpr(YGR214W) OR SimExpr(other) : 18 2

CSRE(1) AND RAP1(1) AND MCM1'(1) => SimExpr(YGR214W) : 9

RAP1(1) AND ALPHA1'(1) AND MCM1'(1) => SimExpr(YGR214W) : 7

HAP234(1) AND MCM1'(1) => SimExpr(YNL069C) OR SimExpr(other) : 9 4

EXPR: (0.212) MCM1' (P < 0.000) HAP234 (P < 0.074)

ORF SYMBOL P F C TF
YDL181W INH1 ATP synthesis coupled proton transport ->
transport proton-transporting ATP synthase complex (sensu Eukarya) ->
cytoplasm, proton-transporting ATP synthase complex, integral to membrane, inner membrane HAP4
YLR304C ACO1 tricarboxylic acid cycle, citrate metabolism, glutamate biosynthesis, propionate metabolism ->
carbohydrate metabolism, amine metabolism, organic acid metabolism, energy pathways, amino acid and derivative metabolism, biosynthesis aconitate hydratase activity ->
carbon-oxygen lyase activity cytosol, mitochondrial matrix ->
cytoplasm CIN5, YAP6
YNL069C RPL16B protein biosynthesis ->
biosynthesis, protein metabolism RNA binding, structural constituent of ribosome ->
RNA binding, structural constituent of ribosome cytosolic large ribosomal subunit (sensu Eukarya) ->
cytoplasm, ribonucleoprotein complex FHL1, GAT3, PDR1, RAP1, RGM1, YAP5
|YPL177C| CUP9 copper ion homeostasis, transcription initiation from Pol II promoter ->
nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, cell homeostasis, transcription specific RNA polymerase II transcription factor activity ->
specific RNA polymerase II transcription factor activity nucleus ->
nucleus BAS1, CIN5, MAC1, PHD1, SWI4, YAP6
|YJL079C| PRY1 nuclear membrane, endoplasmic reticulum ->
nucleus, cytoplasm, endomembrane system NDD1, PHD1, RAP1
YDL137W ARF2 ER to Golgi transport, intra-Golgi transport ->
transport, vesicle-mediated transport ARF small monomeric GTPase activity ->
purine nucleotide binding, hydrolase activity\, acting on acid anhydrides Golgi vesicle, cytosol ->
cytoplasm, Golgi apparatus MSS11, REB1, RGT1, SIG1, SKN7, SOK2
YMR143W RPS16A protein biosynthesis ->
biosynthesis, protein metabolism structural constituent of ribosome ->
structural constituent of ribosome cytosolic small ribosomal subunit (sensu Eukarya) ->
eukaryotic 48S initiation complex, cytoplasm, ribonucleoprotein complex FHL1, GAT3, RAP1, RGM1, YAP5
YPR035W GLN1 nitrogen metabolism, glutamine biosynthesis ->
nitrogen metabolism, amine metabolism, amino acid and derivative metabolism, organic acid metabolism, biosynthesis glutamate-ammonia ligase activity ->
ligase activity\, forming carbon-nitrogen bonds cytoplasm ->
cytoplasm CIN5, DAL81, FKH1, FKH2, GLN3, HSF1, INO4, MSN1, REB1, SWI4
|YNL040W| NO SYMBOL FZF1, GCR2, RTG3, YAP7
|YKL198C| PTK1 polyamine transport ->
transport protein kinase activity ->
transferase activity\, transferring phosphorus-containing groups INO2
YDR377W ATP17 ATP synthesis coupled proton transport ->
transport hydrogen-transporting ATP synthase activity ->
cation transporter activity proton-transporting ATP synthase complex\, coupling factor F(o) (sensu Eukarya) ->
cytoplasm, proton-transporting ATP synthase complex, integral to membrane, inner membrane ARO80, HAP2, HAP3, HAP4, RPH1
YFR033C QCR6 aerobic respiration, oxidative phosphorylation\, ubiquinone to cytochrome c ->
energy pathways, electron transport, phosphorus metabolism ubiquinol-cytochrome c reductase activity ->
oxidoreductase activity\, acting on diphenols and related substances as donors, primary active transporter activity, cation transporter activity mitochondrion, respiratory chain complex III (sensu Eukarya) ->
cytoplasm, respiratory chain complex III, inner membrane HAP4, MBP1
YDL140C RPO21 transcription from Pol II promoter ->
nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism DNA-directed RNA polymerase activity ->
transferase activity\, transferring phosphorus-containing groups DNA-directed RNA polymerase II\, core complex ->
nucleus REB1
Main: biosynthesis (0.36) structural constituent of ribosome (0.20) cytoplasm (0.82) REB1 HAP4 RAP1 CIN5 (0.23)
Score: 0.25 0.07 0.71 0.167
P-value: 4.375E-02 (ATP synthesis coupled proton transport) 1.008E-01 (hydrogen ion transporter activity) 3.537E-02 (proton-transporting ATP synthase complex) 2.498E-02 (HAP4)

CSRE(1) AND RAP1(1) => SimExpr(YNL069C) OR SimExpr(other) : 12 2

CSRE(1) AND HAP234(1) => SimExpr(YNL069C) : 6

CSRE(1) AND RAP1(1) AND MCM1'(1) => SimExpr(YNL069C) : 9

RAP1(1) AND MCM1'(1) => SimExpr(YLR344W) OR SimExpr(other) : 19 1

RAP1(1) AND SWI5(1) => SimExpr(YLR344W) OR SimExpr(other) : 16 7

EXPR: (0.218) SWI5 (P < 0.000) RAP1 (P < 0.150)

CSRE(1) AND RAP1(1) => SimExpr(YLR344W) OR SimExpr(other) : 12 2

RAP1(1) AND SWI5(1) AND SCB(1) => SimExpr(YLR344W) : 5

EXPR: (0.146) SWI5 (P < 0.000) SCB (P < 0.000) RAP1 (P < 0.003)

ORF SYMBOL P F C TF
YMR194W RPL36A protein biosynthesis ->
protein biosynthesis RNA binding, structural constituent of ribosome ->
RNA binding, structural constituent of ribosome cytosolic large ribosomal subunit (sensu Eukarya) ->
cytosol, ribosome ARG80, ARO80, BAS1, CUP9, FHL1, HAL9, HAP4, HAP5, HMS1, MET31, NRG1, RAP1, RCS1, RME1, STP2
YPR080W TEF1 translational elongation ->
protein biosynthesis translation elongation factor activity ->
translation elongation factor activity ribosome ->
ribosome FHL1, PDR1, RAP1, YAP5
YLR249W YEF3 translational elongation ->
protein biosynthesis translation elongation factor activity ->
translation elongation factor activity ribosome ->
ribosome INO2, INO4
YOR369C RPS12 protein biosynthesis ->
protein biosynthesis structural constituent of ribosome ->
structural constituent of ribosome cytosolic small ribosomal subunit (sensu Eukarya) ->
cytosol, eukaryotic 43S pre-initiation complex, eukaryotic 48S initiation complex, ribosome ARG80, FHL1, FKH2, LEU3, NDD1, PDR1, RME1, SMP1, YAP6
YLR344W RPL26A protein biosynthesis ->
protein biosynthesis RNA binding, structural constituent of ribosome ->
RNA binding, structural constituent of ribosome cytosolic large ribosomal subunit (sensu Eukarya) ->
cytosol, ribosome FHL1, RAP1
Main: protein biosynthesis (1.00) structural constituent of ribosome (0.60) ribosome (1.00) FHL1 (0.80)
Score: 1.00 0.40 1.00 0.600
P-value: 1.836E-04 (protein biosynthesis) 1.741E-03 (translation elongation factor activity) 3.393E-05 (ribosome) 9.347E-05 (FHL1)

RAP1(1) AND SWI5(1) AND MCM1'(1) => SimExpr(YLR344W) : 7

RAP1(1) AND ALPHA1'(1) AND MCM1'(1) => SimExpr(YLR344W) : 7

CSRE(1) AND RAP1(1) AND MCM1'(1) => SimExpr(YLR344W) : 9

SFF(1) AND mRRPE(1) AND ECB(1) => SimExpr(YML058W) OR SimExpr(other) : 7 2

EXPR: (0.220) SFF (P < 0.000) mRRPE (P < 0.000) ECB (P < 0.002)

ORF SYMBOL P F C TF
YLR333C RPS25B protein biosynthesis ->
biosynthesis, protein metabolism structural constituent of ribosome ->
structural constituent of ribosome cytosolic small ribosomal subunit (sensu Eukarya) ->
eukaryotic 48S initiation complex, cytoplasm, ribonucleoprotein complex FHL1, RAP1
YOR315W NO SYMBOL ACE2, CIN5, CUP9, FKH2, IXR1, MCM1, NDD1, NRG1, RLM1, ROX1, SKN7, SUM1, SWI4, SWI6, YAP1, YAP6
YDL140C RPO21 transcription from Pol II promoter ->
nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism DNA-directed RNA polymerase activity ->
nucleotidyltransferase activity DNA-directed RNA polymerase II\, core complex ->
nucleus REB1
YNR053C NOG2 mRNA splicing ->
nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism GTPase activity ->
guanyl nucleotide binding, hydrolase activity\, acting on acid anhydrides\, in phosphorus-containing anhydrides nucleus, nucleolus, nucleoplasm ->
nucleus, nucleoplasm ABF1, AZF1
YLR328W NMA1 nicotinamide adenine dinucleotide metabolism ->
coenzymes and prosthetic group metabolism, vitamin metabolism nicotinamide-nucleotide adenylyltransferase activity ->
nucleotidyltransferase activity CIN5, MSN1, ROX1
|YOR066W| NO SYMBOL MBP1, MCM1
|YPL128C| TBF1 loss of chromatin silencing ->
cell organization and biogenesis, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, transcription DNA binding, transcription factor activity ->
DNA binding, transcription factor activity nuclear chromosome\, telomeric region, nuclear chromosome, nucleus ->
chromosome, nucleus
YML058W SML1 response to DNA damage, mitochondrion organization and biogenesis ->
response to biotic stimulus, cell organization and biogenesis enzyme inhibitor activity ->
enzyme inhibitor activity NDD1, RFX1, SWI6
YJL159W HSP150 cell wall organization and biogenesis ->
cell organization and biogenesis structural constituent of cell wall ->
structural constituent of cell wall cell wall ->
cell wall ACE2, HIR2, MCM1, RLM1, SWI5
Main: cell organization and biogenesis (0.43) nucleotidyltransferase activity (0.29) nucleus (0.60) MCM1 (0.38)
Score: 0.29 0.05 0.30 0.179
P-value: 2.826E+00 (transcription\, DNA-dependent) 8.582E-02 (nucleotidyltransferase activity) 7.322E-01 (nucleoplasm) 7.098E-02 (MCM1)

ALPHA1'(1) AND SFF(1) AND mRRPE(1) AND ECB(1) => SimExpr(YML058W) : 6

EXPR: (0.182) ALPHA1' (P < 0.000) SFF (P < 0.000) mRRPE (P < 0.000) ECB (P < 0.000)

ORF SYMBOL P F C TF
YLR333C RPS25B protein biosynthesis ->
biosynthesis, protein metabolism structural constituent of ribosome ->
structural constituent of ribosome cytosolic small ribosomal subunit (sensu Eukarya) ->
cytosolic small ribosomal subunit (sensu Eukarya) FHL1, RAP1
YOR315W NO SYMBOL ACE2, CIN5, CUP9, FKH2, IXR1, MCM1, NDD1, NRG1, RLM1, ROX1, SKN7, SUM1, SWI4, SWI6, YAP1, YAP6
YNR053C NOG2 mRNA splicing ->
nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism GTPase activity ->
GTPase activity nucleus, nucleolus, nucleoplasm ->
nucleus, nucleolus, nucleoplasm ABF1, AZF1
YLR328W NMA1 nicotinamide adenine dinucleotide metabolism ->
coenzymes and prosthetic group metabolism, vitamin metabolism nicotinamide-nucleotide adenylyltransferase activity ->
nicotinamide-nucleotide adenylyltransferase activity CIN5, MSN1, ROX1
YML058W SML1 response to DNA damage, mitochondrion organization and biogenesis ->
response to biotic stimulus, cell organization and biogenesis enzyme inhibitor activity ->
enzyme inhibitor activity NDD1, RFX1, SWI6
YJL159W HSP150 cell wall organization and biogenesis ->
cell organization and biogenesis structural constituent of cell wall ->
structural constituent of cell wall cell wall ->
cell wall ACE2, HIR2, MCM1, RLM1, SWI5
Main: cell organization and biogenesis (0.40) structural constituent of cell wall (0.20) nucleolus (0.33) RLM1 ACE2 SWI6 CIN5 NDD1 ROX1 MCM1 (0.33)
Score: 0.10 0.00 0.00 0.200
P-value: 3.811E+00 (cell organization and biogenesis) 5.051E-01 (structural molecule activity) 3.999E+00 (intracellular) 6.777E-02 (ACE2)

BAS1(1) AND MCB(1) => SimExpr(YGR109C) OR SimExpr(other) : 5 1

EXPR: (0.169) BAS1 (P < 0.000) MCB (P < 0.034)

ORF SYMBOL P F C TF
|YIL066C| RNR3 DNA replication ->
cell proliferation, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism ribonucleoside-diphosphate reductase activity ->
ribonucleoside-diphosphate reductase activity cytoplasm ->
cytoplasm RFX1, STB1
YGR109C CLB6 regulation of CDK activity, G1/S transition of mitotic cell cycle, premeiotic DNA synthesis ->
cell proliferation, cell cycle, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism cyclin-dependent protein kinase\, regulator activity ->
cyclin-dependent protein kinase\, regulator activity MBP1, STB1, SWI4, SWI6
YJR154W NO SYMBOL CIN5, GCN4, RIM101
YHR110W ERP5 secretory pathway ->
transport integral to membrane ->
integral to membrane DOT6, RGT1
YJL181W NO SYMBOL
YPR185W APG13 protein-vacuolar targeting, autophagy ->
cell organization and biogenesis, autophagy, protein metabolism, transport protein binding ->
protein binding extrinsic to membrane ->
extrinsic to membrane MET4, SWI6
Main: cell proliferation (0.50) cyclin-dependent protein kinase\, regulator activity (0.33) extrinsic to membrane (0.33) SWI6 STB1 (0.40)
Score: 0.33 0.00 0.00 0.200
P-value: 1.640E-01 (DNA replication) 2.725E+00 (enzyme activity) 1.666E+00 (membrane) 2.568E-02 (STB1)

MCM1(1) AND MCB(1) => SimExpr(YKR077W) OR SimExpr(other) : 6 3

SFF(1) AND mRRPE(1) AND MCB(1) => SimExpr(YDR279W) OR SimExpr(other) : 5 2

EXPR: (0.205) SFF (P < 0.000) mRRPE (P < 0.000) MCB (P < 0.038)

ORF SYMBOL P F C TF
|YOR033C| EXO1 mismatch repair ->
DNA replication and chromosome cycle, DNA repair, mitotic cell cycle, DNA metabolism exonuclease activity, flap endonuclease activity, 5'-3' exonuclease activity ->
DNA binding, nuclease activity nucleus ->
nucleus RGT1
YFR031C SMC2 mitotic chromosome condensation, mitotic chromosome segregation ->
DNA replication and chromosome cycle, M phase of mitotic cell cycle, M phase DNA secondary structure binding, AT DNA binding, double-stranded DNA binding, ATPase activity ->
DNA binding, double-stranded DNA binding, purine nucleotide binding, hydrolase activity\, acting on acid anhydrides nuclear condensin complex ->
chromosome, nucleus INO2, MET4
YMR279C NO SYMBOL IXR1, MIG1, MTH1, RFX1, SWI4, SWI6
YNL102W POL1 DNA replication\, priming, DNA replication initiation, lagging strand elongation, DNA repair synthesis ->
DNA replication and chromosome cycle, mitotic recombination, mitotic cell cycle, DNA metabolism, DNA repair alpha DNA polymerase activity ->
transferase activity\, transferring phosphorus-containing groups alpha DNA polymerase\:primase complex ->
nucleus LEU3, MBP1
|YDR093W| DNF2 intracellular protein transport ->
intracellular protein transport phospholipid-translocating ATPase activity ->
phospholipid binding, purine nucleotide binding, primary active transporter activity, cation transporter activity, hydrolase activity\, acting on acid anhydrides plasma membrane ->
plasma membrane GTS1
YDR279W RNH202 GCR2, MBP1, RIM101, RLM1, SWI6, THI2
YJR001W AVT1 neutral amino acid transport ->
amine/polyamine transport, carboxylic acid transport neutral amino acid transporter activity ->
carboxylic acid transporter activity vacuole ->
cytoplasm CRZ1, GAT3, MATa1
Main: DNA replication and chromosome cycle (0.60) DNA binding (0.40) nucleus (0.60) MBP1 SWI6 (0.29)
Score: 0.30 0.20 0.30 0.095
P-value: 1.005E-01 (DNA replication and chromosome cycle) 6.142E-01 (ATPase activity) 2.364E+00 (nucleus) 3.407E-01 (SWI6)

MCM1(1) AND PDR(1) => SimExpr(YOR273C) OR SimExpr(other) : 8 3

EXPR: (0.234) PDR (P < 0.009) MCM1 (P < 0.014)

RAP1(1) AND MCM1'(1) => SimExpr(YGR085C) OR SimExpr(other) : 18 2

RAP1(1) AND ALPHA1(1) AND MCM1'(1) => SimExpr(YGR085C) : 9

HAP234(1) AND MCM1'(1) => SimExpr(YMR143W) OR SimExpr(other) : 9 4

RAP1(1) AND SWI5(1) AND SCB(1) => SimExpr(YMR194W) : 5

RAP1(1) AND MCM1'(1) => SimExpr(YMR142C) OR SimExpr(other) : 18 2

RAP1(1) AND ALPHA1(1) AND MCM1'(1) => SimExpr(YMR142C) : 9

RAP1(1) AND ALPHA1'(1) AND MCM1'(1) => SimExpr(YMR142C) : 7

RAP1(1) AND mRRPE(1) => SimExpr(YMR116C) OR SimExpr(other) : 7 3

RAP1(1) AND SWI5(1) AND SCB(1) => SimExpr(YOR369C) : 5

RAP1(1) AND mRRPE(1) => SimExpr(YDL130W) OR SimExpr(other) : 7 3

RAP1(1) AND MCM1'(1) => SimExpr(YDL130W) OR SimExpr(other) : 18 2

RAP1(1) AND ALPHA1'(1) AND MCM1'(1) => SimExpr(YDL130W) : 7

RAP1(1) AND ALPHA1(1) AND MCM1'(1) => SimExpr(YDL130W) : 9

RAP1(1) AND PDR(1) => SimExpr(YML026C) OR SimExpr(other) : 5 1

EXPR: (0.161) PDR (P < 0.000) RAP1 (P < 0.122)

RAP1(1) AND mRRPE(1) => SimExpr(YGL030W) OR SimExpr(other) : 7 3

RAP1(1) AND MCM1'(1) => SimExpr(YJR139C) OR SimExpr(other) : 18 2

RAP1(1) AND ALPHA2(1) => SimExpr(YJR139C) OR SimExpr(other) : 5 2

EXPR: (0.223) ALPHA2 (P < 0.000) RAP1 (P < 0.061)

ORF SYMBOL P F C TF
YMR142C RPL13B protein biosynthesis ->
biosynthesis, protein metabolism structural constituent of ribosome ->
structural constituent of ribosome cytosolic large ribosomal subunit (sensu Eukarya) ->
cytoplasm, ribonucleoprotein complex FHL1, GAT3, RAP1, RGM1, YAP5
YLR249W YEF3 translational elongation ->
biosynthesis, protein metabolism translation elongation factor activity ->
translation elongation factor activity ribosome ->
cytoplasm, ribonucleoprotein complex INO2, INO4
YJR139C HOM6 homoserine biosynthesis, methionine metabolism, threonine metabolism ->
amine metabolism, sulfur metabolism, biosynthesis, amino acid and derivative metabolism, organic acid metabolism homoserine dehydrogenase activity ->
homoserine dehydrogenase activity HMS1, RAP1
YOR369C RPS12 protein biosynthesis ->
biosynthesis, protein metabolism structural constituent of ribosome ->
structural constituent of ribosome cytosolic small ribosomal subunit (sensu Eukarya) ->
eukaryotic 48S initiation complex, cytoplasm, ribonucleoprotein complex ARG80, FHL1, FKH2, LEU3, NDD1, PDR1, RME1, SMP1, YAP6
|YPL162C| NO SYMBOL
|YDL043C| PRP11 spliceosome assembly ->
nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism RNA binding ->
RNA binding snRNP U2 ->
nucleus, ribonucleoprotein complex DAL81, STP1
YNL311C NO SYMBOL GCN4, RAP1
Main: biosynthesis (0.80) structural constituent of ribosome (0.40) ribonucleoprotein complex (1.00) RAP1 (0.50)
Score: 0.60 0.10 1.00 0.267
P-value: 3.052E-01 (protein biosynthesis) 3.977E-01 (structural constituent of ribosome) 3.008E-02 (ribonucleoprotein complex) 1.209E-01 (RAP1)

RAP1(1) AND ALPHA1(1) AND MCM1'(1) => SimExpr(YJR139C) : 9

RAP1(1) AND MCM1'(1) => SimExpr(YKL006W) OR SimExpr(other) : 18 2

RAP1(1) AND ALPHA1(1) AND MCM1'(1) => SimExpr(YKL006W) : 9

RAP1(1) AND PDR(1) => SimExpr(YLR441C) OR SimExpr(other) : 5 1

RAP1(1) AND MCM1'(1) => SimExpr(YIL018W) OR SimExpr(other) : 18 2

RAP1(1) AND ALPHA1(1) AND MCM1'(1) => SimExpr(YIL018W) : 9

RAP1(1) AND mRRPE(1) => SimExpr(YLR249W) OR SimExpr(other) : 7 3

RAP1(1) AND ALPHA1(1) AND SFF(1) => SimExpr(YLR249W) OR SimExpr(other) : 12 5

RAP1(1) AND SWI5(1) AND SCB(1) => SimExpr(YLR249W) : 5

RAP1(1) AND PDR(1) => SimExpr(YNL096C) OR SimExpr(other) : 5 1

RAP1(1) AND mRRPE(1) => SimExpr(YPR080W) OR SimExpr(other) : 7 3

RAP1(1) AND SWI5(1) AND SCB(1) => SimExpr(YPR080W) : 5

ndt80(MSE)(1) AND mRRPE(1) => SimExpr(YFR023W) OR SimExpr(other) : 5 2

EXPR: (0.195) ndt80(MSE) (P < 0.025) mRRPE (P < 0.001)

ORF SYMBOL P F C TF
YHR184W SSP1 spore wall assembly (sensu Saccharomyces), protein complex assembly ->
protein metabolism, sporulation prospore membrane ->
prospore SUM1
YOR338W NO SYMBOL RAP1
YOL091W SPO21 spore wall assembly (sensu Saccharomyces), meiosis ->
cell proliferation, sporulation structural molecule activity ->
structural molecule activity spindle pole body ->
cytoplasm HAP5, SUM1
YOR339C UBC11 protein polyubiquitination, protein monoubiquitination ->
catabolism, protein metabolism ubiquitin conjugating enzyme activity ->
ubiquitin conjugating enzyme activity cytoplasm ->
cytoplasm HAP2, IXR1
|YGL253W| HXK2 fructose metabolism ->
alcohol metabolism, carbohydrate metabolism hexokinase activity ->
hexokinase activity nucleus, cytosol ->
nucleus, cytoplasm ABF1, CIN5, HSF1, SWI4
|YJR007W| SUI2 translational initiation ->
biosynthesis, protein metabolism translation initiation factor activity ->
translation initiation factor activity ribosome, cytoplasm ->
cytoplasm, ribonucleoprotein complex GLN3, HAP3, HIR1, RCS1
YFR023W PES4 DNA dependent DNA replication ->
cell proliferation, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism DIG1, FKH1, FKH2, GLN3, HAP3, MCM1, MSN2, RIM101, RLM1, RTG3, STE12, SUM1, THI2, YAP1
Main: protein metabolism (0.50) ubiquitin conjugating enzyme activity (0.25) cytoplasm (0.80) SUM1 (0.43)
Score: 0.33 0.00 0.60 0.190
P-value: 1.686E-02 (spore wall assembly (sensu Saccharomyces)) 2.849E+00 (enzyme activity) 3.294E+00 (cytoplasm) 4.371E-03 (SUM1)

ALPHA1(1) AND ALPHA2(1) AND MCB(1) => SimExpr(YOR144C) OR SimExpr(other) : 5 2

EXPR: (0.191) ALPHA2 (P < 0.000) MCB (P < 0.066) ALPHA1 (P < 0.000)

ORF SYMBOL P F C TF
|YPL140C| MKK2 protein amino acid phosphorylation, signal transduction ->
phosphate metabolism, signal transduction, protein modification MAP kinase kinase activity ->
protein kinase activity intracellular ->
intracellular FKH1, FKH2
YNL082W PMS1 mismatch repair, meiosis ->
DNA repair, cell cycle, DNA metabolism ATPase activity, ATP binding, DNA binding ->
ATP binding, DNA binding, hydrolase activity\, acting on acid anhydrides\, in phosphorus-containing anhydrides nuclear chromosome ->
intracellular MTH1
YPR185W APG13 protein-vacuolar targeting, autophagy ->
cytoplasm organization and biogenesis, autophagy, intracellular transport, protein metabolism, protein transport protein binding ->
protein binding extrinsic to membrane ->
extrinsic to membrane MET4, SWI6
|YJL095W| BCK1 protein amino acid phosphorylation, protein kinase cascade, response to nutrients, establishment of cell polarity (sensu Saccharomyces) ->
phosphate metabolism, intracellular signaling cascade, response to extracellular stimulus, cytoplasm organization and biogenesis, protein modification, response to chemical substance MAP kinase kinase kinase activity ->
protein kinase activity intracellular ->
intracellular YAP1
YFR027W ECO1 sister chromatid cohesion, DNA replication, DNA repair ->
DNA metabolism, cell cycle acetyltransferase activity ->
acyltransferase activity nuclear chromatin ->
intracellular
YOR284W HUA2 RFX1, YAP6
YOR144C ELG1 negative regulation of DNA transposition, negative regulation of DNA recombination ->
DNA metabolism YJL206C
Main: DNA metabolism (0.50) protein kinase activity (0.40) intracellular (0.80) YAP1 (0.17)
Score: 0.33 0.10 0.60 0.000
P-value: 3.096E-01 (protein amino acid phosphorylation) 3.795E-01 (protein kinase activity) 1.705E-01 (chromosome) 7.321E-01 (YJL206C)

ALPHA1(1) AND ALPHA1'(1) AND SFF(1) AND AFT1(1) => SimExpr(YHL035C) OR SimExpr(other) : 6 2

EXPR: (0.222) ALPHA1' (P < 0.000) SFF (P < 0.000) AFT1 (P < 0.001) ALPHA1 (P < 0.000)

ORF SYMBOL P F C TF
YMR083W ADH3 fermentation ->
fermentation alcohol dehydrogenase activity ->
alcohol dehydrogenase activity mitochondrial matrix, soluble fraction ->
mitochondrial matrix, soluble fraction RAP1
|YOR389W| NO SYMBOL MCM1, YJL206C
YHL035C NO SYMBOL YFL044C
YMR253C NO SYMBOL MCM1
YMR088C NO SYMBOL
|YHR209W| NO SYMBOL LEU3
YOR381W FRE3 iron-siderochrome transport, iron ion homeostasis ->
iron-siderochrome transport, iron ion homeostasis ferric-chelate reductase activity ->
ferric-chelate reductase activity plasma membrane, integral to membrane ->
plasma membrane, integral to membrane CIN5, PDR1, YAP6
YKL167C MRP49 protein biosynthesis ->
protein biosynthesis structural constituent of ribosome ->
structural constituent of ribosome mitochondrial large ribosomal subunit ->
mitochondrial matrix, large ribosomal subunit, organellar ribosome ABF1, IME4, IXR1
Main: iron ion homeostasis (0.33) ferric-chelate reductase activity (0.33) mitochondrial matrix (0.67) MCM1 (0.29)
Score: 0.00 0.00 0.33 0.048
P-value: 3.993E+00 (metabolism) 4.865E-01 (oxidoreductase activity) 2.572E-01 (mitochondrial matrix) 3.069E-01 (MCM1)

ABF1(1) AND SFF(1) AND PAC(1) => SimExpr(YKL014C) OR SimExpr(other) : 6 1

EXPR: (0.194) ABF1 (P < 0.000) SFF (P < 0.000) PAC (P < 0.005)

ORF SYMBOL P F C TF
YKL078W DHR2 ribosome biogenesis ->
cytoplasm organization and biogenesis RNA helicase activity ->
RNA binding nucleolus ->
nucleus ABF1
YNL292W PUS4 tRNA modification ->
RNA metabolism pseudouridylate synthase activity ->
carbon-oxygen lyase activity mitochondrion, nucleus ->
cytoplasm, nucleus RCS1
|YGR283C| NO SYMBOL ACE2, RAP1, SMP1
YGR187C HGH1 ABF1, HAP3, HIR1, RCS1, RTG1
YKL014C NO SYMBOL ABF1
YOL041C NOP12 rRNA metabolism ->
RNA metabolism RNA binding ->
RNA binding nucleolus ->
nucleus GTS1, MET31
YJL069C UTP18 ABF1
Main: RNA metabolism (0.67) RNA binding (0.67) nucleus (1.00) ABF1 (0.57)
Score: 0.33 0.33 1.00 0.333
P-value: 5.684E-01 (RNA metabolism) 6.158E-01 (RNA binding) 1.881E-01 (nucleolus) 6.557E-03 (ABF1)

ABF1(1) AND mRRPE(1) AND PAC(1) => SimExpr(YKL014C) OR SimExpr(other) : 8 2

EXPR: (0.202) ABF1 (P < 0.000) mRRPE (P < 0.000) PAC (P < 0.003)

ORF SYMBOL P F C TF
YNL292W PUS4 tRNA modification ->
nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism pseudouridylate synthase activity ->
pseudouridylate synthase activity mitochondrion, nucleus ->
cytoplasm, nucleus RCS1
YPR010C RPA135 transcription from Pol I promoter ->
nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism DNA-directed RNA polymerase activity ->
DNA-directed RNA polymerase activity DNA-directed RNA polymerase I complex ->
nucleus ROX1, SIG1
|YNR046W| NO SYMBOL ABF1
YJL050W MTR4 35S primary transcript processing ->
cell organization and biogenesis, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism ATP dependent RNA helicase activity ->
RNA helicase activity, ATP dependent helicase activity, RNA dependent ATPase activity nucleolus ->
nucleus
YKL172W EBP2 rRNA processing ->
cell organization and biogenesis, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism nucleolus ->
nucleus ABF1, FZF1, RFX1
|YLR197W| SIK1 rRNA modification, 35S primary transcript processing, processing of 20S pre-rRNA ->
cell organization and biogenesis, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, transcription small nuclear ribonucleoprotein complex, small nucleolar ribonucleoprotein complex, nucleus, nucleolus ->
nucleus, ribonucleoprotein complex DAL81, HAL9
YGR187C HGH1 ABF1, HAP3, HIR1, RCS1, RTG1
YKL014C NO SYMBOL ABF1
YNL112W DBP2 RNA helicase activity ->
RNA helicase activity bud neck ->
site of polarized growth (sensu Fungi)
YJL069C UTP18 ABF1
Main: nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism (1.00) RNA helicase activity (0.50) nucleus (0.83) ABF1 (0.62)
Score: 1.00 0.17 0.67 0.393
P-value: 5.515E-03 (transcription from Pol I promoter) 4.187E-02 (RNA helicase activity) 2.839E-03 (nucleolus) 3.110E-03 (ABF1)

ABF1(1) AND ALPHA1'(1) AND PAC(1) => SimExpr(YKL014C) : 5

ABF1(1) AND SFF(1) AND PAC(1) => SimExpr(YGR187C) OR SimExpr(other) : 5 2

ABF1(1) AND ALPHA1'(1) AND PAC(1) => SimExpr(YOL041C) : 5

ABF1(1) AND SFF(1) AND PAC(1) => SimExpr(YNL292W) OR SimExpr(other) : 6 1

LYS14(1) AND mRRPE(1) AND MCM1'(1) => SimExpr(YML093W) OR SimExpr(other) : 6 2

EXPR: (0.212) LYS14 (P < 0.000) mRRPE (P < 0.000) MCM1' (P < 0.000)

ORF SYMBOL P F C TF
|YNL042W| BOP3 DAL82
YGR280C PXR1 35S primary transcript processing, snRNA processing ->
cell organization and biogenesis, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism RNA binding ->
RNA binding nucleolus ->
nucleus
YDL140C RPO21 transcription from Pol II promoter ->
nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism DNA-directed RNA polymerase activity ->
transferase activity\, transferring phosphorus-containing groups DNA-directed RNA polymerase II\, core complex ->
nucleus REB1
YML093W UTP14 processing of 20S pre-rRNA ->
cell organization and biogenesis, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism snoRNA binding ->
RNA binding small nucleolar ribonucleoprotein complex ->
nucleus, ribonucleoprotein complex
YOL130W ALR1 di-\, tri-valent inorganic cation transport, magnesium ion transport ->
transport di-\, tri-valent inorganic cation transporter activity ->
cation transporter activity plasma membrane ->
plasma membrane
|YLR328W| NMA1 nicotinamide adenine dinucleotide metabolism ->
coenzymes and prosthetic group metabolism, vitamin metabolism nicotinamide-nucleotide adenylyltransferase activity ->
transferase activity\, transferring phosphorus-containing groups CIN5, MSN1, ROX1
YDL088C ASM4 protein-nucleus import\, docking, mRNA-nucleus export, rRNA-nucleus export, snRNA-nucleus export, NLS-bearing substrate-nucleus import, snRNP protein-nucleus import, mRNA-binding (hnRNP) protein-nucleus import, ribosomal protein-nucleus import, protein-nucleus export, nuclear pore organization and biogenesis ->
intracellular transport, nuclear organization and biogenesis, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, protein metabolism, transport structural molecule activity ->
structural molecule activity nuclear pore ->
nucleus, integral to membrane, endomembrane system
YMR042W ARG80 positive regulation of transcription from Pol II promoter, arginine metabolism ->
amine metabolism, nitrogen metabolism, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, amino acid and derivative metabolism, organic acid metabolism DNA binding, specific RNA polymerase II transcription factor activity ->
DNA binding, specific RNA polymerase II transcription factor activity nucleus ->
nucleus RME1
Main: nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism (0.71) RNA binding (0.29) nucleus (0.83) DAL82 (0.25)
Score: 0.52 0.10 0.67 0.000
P-value: 1.624E-01 (transcription\, DNA-dependent) 7.594E-02 (nucleotidyltransferase activity) 2.848E-01 (nucleolus) 2.035E-01 (MSN1)

LYS14(1) AND mRRPE(1) AND PAC(1) => SimExpr(YML093W) OR SimExpr(other) : 6 2

LYS14(1) AND mRRPE(1) AND PAC(1) => SimExpr(YHR052W) OR SimExpr(other) : 7 1

AVERAGE SCORES:

P
  SCORE: 0.544 (Part of genes covered by "Main": 0.672) (No. rules=39/39)
  P-VALUE: 0.462
F
  SCORE: 0.181 (Part of genes covered by "Main": 0.418) (No. rules=39/39)
  P-VALUE: 0.308
C
  SCORE: 0.604 (Part of genes covered by "Main": 0.753) (No. rules=39/39)
  P-VALUE: 0.410
TF
  SCORE: 0.353 (Part of genes covered by "Main": 0.515) (No. rules=39/39)
  P-VALUE: 0.538
EXPRESSION: 0.718 (39)

ORF	SYMBOL	P	F	C	TF
YJR070C	NO SYMBOL				GAT3, YAP5
YHR052W	CIC1	protein catabolism -> macromolecule catabolism, protein metabolism	protein binding\, bridging -> protein binding\, bridging	nucleolus, proteasome complex (sensu Eukarya) -> nucleus, cytoplasm	HAP4, MATa1
YGL099W	LSG1	conjugation with cellular fusion, sporulation (sensu Saccharomyces), ribosome nucleus export -> conjugation with cellular fusion, sporulation (sensu Fungi), cytoplasm organization and biogenesis, intracellular transport, protein metabolism, protein transport	GTPase activity -> purine nucleotide binding, hydrolase activity\, acting on acid anhydrides	cytoplasm -> cytoplasm	PHO4
YGR280C	PXR1	35S primary transcript processing, snRNA processing -> cytoplasm organization and biogenesis, RNA metabolism, transcription	RNA binding -> RNA binding	nucleolus -> nucleus
YML093W	UTP14	processing of 20S pre-rRNA -> cytoplasm organization and biogenesis, RNA metabolism, transcription	snoRNA binding -> RNA binding	small nucleolar ribonucleoprotein complex -> nucleus, ribonucleoprotein complex
YNL110C	NOP15	ribosomal large subunit biogenesis -> cytoplasm organization and biogenesis		nucleus, nucleolus -> nucleus
\|YMR290C\|	HAS1			nucleolus, nuclear membrane -> nucleus, endomembrane system	RAP1
\|YMR259C\|	NO SYMBOL				ARG80, GCR2, GTS1, HIR1, SRD1
Main:		cytoplasm organization and biogenesis (0.80)	RNA binding (0.50)	nucleus (0.83)	GCR2 (0.20)
Score:		0.70	0.17	0.73	0.000
P-value:		3.295E-03 (ribosome biogenesis)	6.494E-01 (RNA binding)	3.761E-05 (nucleolus)	9.470E-01 (MATa1)

ORF	SYMBOL	P	F	C	TF
\|YGL062W\|	PYC1	NADPH regeneration, gluconeogenesis -> coenzymes and prosthetic group metabolism, alcohol metabolism, carbohydrate metabolism, vitamin metabolism, biosynthesis, energy pathways	pyruvate carboxylase activity -> pyruvate carboxylase activity	cytosol -> cytoplasm	DIG1, GCR1, STE12
YKL085W	MDH1	tricarboxylic acid cycle, malate metabolism -> carbohydrate metabolism, organic acid metabolism, energy pathways	L-malate dehydrogenase activity -> L-malate dehydrogenase activity	mitochondrial matrix -> cytoplasm	IME4, MTH1, RTG1, YJL206C
YIL052C	RPL34B	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytoplasm, ribonucleoprotein complex	RME1
YNL098C	RAS2	pseudohyphal growth, sporulation (sensu Saccharomyces), adenylate cyclase activation, RAS protein signal transduction -> cell organization and biogenesis, sporulation, signal transduction	RAS small monomeric GTPase activity -> RAS small monomeric GTPase activity	plasma membrane -> plasma membrane	ACE2, SKN7
YMR291W	NO SYMBOL				RAP1
YDR276C	PMP3	cation transport -> transport		plasma membrane -> plasma membrane	GAT1
Main:		energy pathways (0.40)	pyruvate carboxylase activity (0.25)	cytoplasm (0.60)	RTG1 (0.17)
Score:		0.20	0.00	0.40	0.000
P-value:		8.572E-02 (main pathways of carbohydrate metabolism)	2.077E+00 (enzyme activity)	4.197E-01 (plasma membrane)	5.170E-01 (GAT1)

ORF	SYMBOL	P	F	C	TF
\|YPL180W\|	BIT89	glycerol metabolism -> alcohol metabolism, glycerol ether metabolism, lipid metabolism			REB1, RGT1, SIG1
YMR230W	RPS10B	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya) -> cytosol, eukaryotic 43S pre-initiation complex, eukaryotic 48S initiation complex, ribosome	FHL1, RAP1
YKL006W	RPL14A	protein biosynthesis -> biosynthesis, protein metabolism	RNA binding, structural constituent of ribosome -> RNA binding, structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytosol, ribosome	FHL1, GAT3, GRF10(Pho2), GTS1, RAP1
YIL018W	RPL2B	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytosol, ribosome	FHL1, GAT3, PDR1, RAP1, RGM1, SWI5, YAP5
YGR254W	ENO1	gluconeogenesis, glycolysis -> alcohol metabolism, carbohydrate biosynthesis, carbohydrate metabolism, energy derivation by oxidation of organic compounds, biosynthesis, catabolism	phosphopyruvate hydratase activity -> phosphopyruvate hydratase activity	phosphopyruvate hydratase complex, cytoplasm -> cytosol, cytoplasm	FKH2, MSN4, PDR1, SWI5, YAP5
\|YLR452C\|	SST2	signal transduction, adaptation to pheromone during conjugation with cellular fusion -> signal transduction, conjugation, perception of external stimulus, sexual reproduction, response to abiotic stimulus	GTPase activator activity -> GTPase activator activity	plasma membrane -> plasma membrane	DIG1, FHL1, RAP1, STE12
YNL069C	RPL16B	protein biosynthesis -> biosynthesis, protein metabolism	RNA binding, structural constituent of ribosome -> RNA binding, structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytosol, ribosome	FHL1, GAT3, PDR1, RAP1, RGM1, YAP5
YDL130W	RPP1B	protein biosynthesis, translational elongation -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytosol, ribosome	FHL1, GAL4, RAP1, RFX1
YPL090C	RPS6A	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya) -> cytosol, eukaryotic 43S pre-initiation complex, eukaryotic 48S initiation complex, ribosome	FHL1, GAT3, INO4, RAP1, YAP5
YJR139C	HOM6	homoserine biosynthesis, methionine metabolism, threonine metabolism -> amine metabolism, sulfur metabolism, biosynthesis, amino acid and derivative metabolism, organic acid metabolism	homoserine dehydrogenase activity -> homoserine dehydrogenase activity		HMS1, RAP1
YMR142C	RPL13B	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytosol, ribosome	FHL1, GAT3, RAP1, RGM1, YAP5
YGL147C	RPL9A	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytosol, ribosome	FHL1, MBP1, RAP1, SWI4
YGL030W	RPL30	protein biosynthesis, rRNA processing, mRNA splicing, regulation of translation -> cell organization and biogenesis, biosynthesis, transcription, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya), cytoplasm -> cytosol, cytoplasm, ribosome	FHL1, GAT3, RAP1, SFP1
YOL120C	RPL18A	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytosol, ribosome	FHL1, MAL13, RAP1, YAP5
YML073C	RPL6A	protein biosynthesis, ribosomal large subunit assembly and maintenance -> biosynthesis, cell organization and biogenesis, protein metabolism	RNA binding, structural constituent of ribosome -> RNA binding, structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytosol, ribosome	FHL1, GAT3, RAP1, YAP5
YGR214W	RPS0A	protein biosynthesis, ribosomal small subunit assembly and maintenance -> biosynthesis, cell organization and biogenesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya) -> cytosol, eukaryotic 43S pre-initiation complex, eukaryotic 48S initiation complex, ribosome	FHL1, RAP1
YDR450W	RPS18A	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya) -> cytosol, eukaryotic 43S pre-initiation complex, eukaryotic 48S initiation complex, ribosome	FHL1, GAT3, HIR2, RAP1, RGM1, YAP5
YKL152C	GPM1	gluconeogenesis, glycolysis -> alcohol metabolism, carbohydrate biosynthesis, carbohydrate metabolism, energy derivation by oxidation of organic compounds, biosynthesis, catabolism	phosphoglycerate mutase activity -> phosphoglycerate mutase activity	cytosol -> cytosol	GCR1, GCR2, HSF1, RAP1
YLR344W	RPL26A	protein biosynthesis -> biosynthesis, protein metabolism	RNA binding, structural constituent of ribosome -> RNA binding, structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytosol, ribosome	FHL1, RAP1
YGR085C	RPL11B	protein biosynthesis, ribosomal large subunit assembly and maintenance -> biosynthesis, cell organization and biogenesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytosol, ribosome	FHL1, MIG1
Main:		biosynthesis (0.90)	structural constituent of ribosome (0.79)	cytosol (0.94)	RAP1 (0.85)
Score:		0.82	0.61	0.89	0.832
P-value:		1.901E-09 (protein biosynthesis)	2.406E-14 (structural constituent of ribosome)	3.100E-16 (cytosolic ribosome (sensu Eukarya))	1.225E-20 (FHL1)

ORF	SYMBOL	P	F	C	TF
YMR116C	ASC1			cytoplasm -> cytoplasm	FHL1, RAP1
YLR249W	YEF3	translational elongation -> macromolecule biosynthesis, protein metabolism	translation elongation factor activity -> translation elongation factor activity	ribosome -> cytoplasm, ribonucleoprotein complex	INO2, INO4
YDL130W	RPP1B	protein biosynthesis, translational elongation -> macromolecule biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytoplasm, ribonucleoprotein complex	FHL1, GAL4, RAP1, RFX1
\|YMR013C\|	SEC59	protein-ER targeting, protein amino acid glycosylation -> cytoplasm organization and biogenesis, macromolecule biosynthesis, intracellular transport, secretory pathway, protein modification, glycoprotein metabolism, protein metabolism, protein transport	dolichol kinase activity -> dolichol kinase activity	membrane -> membrane	FHL1, NDD1, RAP1, RLM1, RME1
\|YDR449C\|	UTP6	processing of 20S pre-rRNA -> cytoplasm organization and biogenesis, RNA metabolism, transcription	snoRNA binding -> snoRNA binding	small nucleolar ribonucleoprotein complex -> nucleus, ribonucleoprotein complex	FHL1, GAT3, HIR2, RAP1, RGM1, YAP5
YGL030W	RPL30	protein biosynthesis, rRNA processing, mRNA splicing, regulation of translation -> cytoplasm organization and biogenesis, macromolecule biosynthesis, transcription\, DNA-dependent, RNA metabolism, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya), cytoplasm -> cytoplasm, ribonucleoprotein complex	FHL1, GAT3, RAP1, SFP1
YOL120C	RPL18A	protein biosynthesis -> macromolecule biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytoplasm, ribonucleoprotein complex	FHL1, MAL13, RAP1, YAP5
\|YMR014W\|	BUD22	bud site selection -> cytokinesis, cytoplasm organization and biogenesis		nucleus -> nucleus	CUP9, HAL9, HIR2, LEU3, NDD1, RLM1, ROX1, SMP1, YAP6
YOL121C	RPS19A	protein biosynthesis -> macromolecule biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya) -> eukaryotic 48S initiation complex, cytoplasm, ribonucleoprotein complex	AZF1, FHL1, GCR1, GCR2, HAL9, MET31, MOT3, PDR1, RAP1, ROX1, RPH1, SMP1, YAP6, ZAP1
YPR080W	TEF1	translational elongation -> macromolecule biosynthesis, protein metabolism	translation elongation factor activity -> translation elongation factor activity	ribosome -> cytoplasm, ribonucleoprotein complex	FHL1, PDR1, RAP1, YAP5
Main:		protein metabolism (0.78)	structural constituent of ribosome (0.50)	cytoplasm (0.70)	RAP1 FHL1 (0.80)
Score:		0.72	0.25	0.62	0.689
P-value:		3.639E-04 (translational elongation)	6.981E-03 (translation elongation factor activity)	1.478E-04 (ribonucleoprotein complex)	6.276E-10 (FHL1)

ORF	SYMBOL	P	F	C	TF
\|YKL141W\|	SDH3	oxidative phosphorylation\, succinate to ubiquinone, tricarboxylic acid cycle -> electron transport, carbohydrate metabolism, phosphorus metabolism, energy pathways	succinate dehydrogenase activity -> succinate dehydrogenase activity	respiratory chain complex II (sensu Eukarya) -> cytoplasm, respiratory chain complex II, succinate dehydrogenase complex (ubiquinone), inner membrane
YPR145W	ASN1	asparagine biosynthesis -> amine metabolism, amino acid and derivative metabolism, organic acid metabolism, biosynthesis	asparagine synthase (glutamine-hydrolyzing) activity -> asparagine synthase (glutamine-hydrolyzing) activity		DAL81, GCN4, GLN3, MET4, RAP1, SUM1
YLR304C	ACO1	tricarboxylic acid cycle, citrate metabolism, glutamate biosynthesis, propionate metabolism -> carbohydrate metabolism, amine metabolism, organic acid metabolism, energy pathways, amino acid and derivative metabolism, biosynthesis	aconitate hydratase activity -> aconitate hydratase activity	cytosol, mitochondrial matrix -> cytoplasm	CIN5, YAP6
YNL069C	RPL16B	protein biosynthesis -> biosynthesis, protein metabolism	RNA binding, structural constituent of ribosome -> RNA binding, structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytoplasm, ribonucleoprotein complex	FHL1, GAT3, PDR1, RAP1, RGM1, YAP5
YOR136W	IDH2	tricarboxylic acid cycle, isocitrate metabolism, glutamate biosynthesis -> carbohydrate metabolism, amine metabolism, organic acid metabolism, energy pathways, amino acid and derivative metabolism, biosynthesis	isocitrate dehydrogenase (NAD+) activity -> isocitrate dehydrogenase (NAD+) activity	mitochondrial matrix, mitochondrion -> cytoplasm	MET4
YFR033C	QCR6	aerobic respiration, oxidative phosphorylation\, ubiquinone to cytochrome c -> energy pathways, electron transport, phosphorus metabolism	ubiquinol-cytochrome c reductase activity -> ubiquinol-cytochrome c reductase activity	mitochondrion, respiratory chain complex III (sensu Eukarya) -> cytoplasm, respiratory chain complex III, inner membrane	HAP4, MBP1
Main:		biosynthesis (0.67)	RNA binding (0.17)	cytoplasm (1.00)	RAP1 MET4 (0.40)
Score:		0.73	0.00	1.00	0.200
P-value:		4.809E-05 (tricarboxylic acid cycle)	3.006E-02 (oxidoreductase activity)	7.682E-03 (mitochondrial electron transport chain)	5.318E-02 (MET4)

ORF	SYMBOL	P	F	C	TF
YOR152C	NO SYMBOL				HIR2
YNL197C	WHI3	regulation of cell size -> cell organization and biogenesis	RNA binding -> RNA binding		REB1
YNL111C	CYB5	sterol biosynthesis -> alcohol metabolism, biosynthesis, lipid metabolism	electron transporter activity -> electron transporter activity	microsome -> microsome	ABF1, GCR2, GTS1, NRG1, REB1, ROX1
YNL090W	RHO2	microtubule-based process, cell wall organization and biogenesis, small GTPase mediated signal transduction, establishment of cell polarity (sensu Saccharomyces), actin filament organization -> signal transduction, cell organization and biogenesis, organelle organization and biogenesis	Rho small monomeric GTPase activity, signal transducer activity -> Rho small monomeric GTPase activity, signal transducer activity	intracellular -> intracellular	INO4, REB1
YOR025W	HST3	chromatin silencing at telomere, short-chain fatty acid metabolism -> cell organization and biogenesis, lipid metabolism, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, transcription, organic acid metabolism	DNA binding -> DNA binding	intracellular -> intracellular	IXR1, NDD1
Main:		cell organization and biogenesis (0.75)	DNA binding (0.25)	intracellular (0.67)	REB1 (0.60)
Score:		0.67	0.00	0.33	0.300
P-value:		1.465E-01 (lipid metabolism)	7.055E-01 (binding)	3.995E+00 (intracellular)	5.118E-03 (REB1)

ORF	SYMBOL	P	F	C	TF
YGL062W	PYC1	NADPH regeneration, gluconeogenesis -> coenzymes and prosthetic group metabolism, alcohol metabolism, carbohydrate metabolism, vitamin metabolism, biosynthesis, energy pathways	pyruvate carboxylase activity -> pyruvate carboxylase activity	cytosol -> cytoplasm	DIG1, GCR1, STE12
YKL141W	SDH3	oxidative phosphorylation\, succinate to ubiquinone, tricarboxylic acid cycle -> electron transport, carbohydrate metabolism, phosphorus metabolism, energy pathways	succinate dehydrogenase activity -> succinate dehydrogenase activity	respiratory chain complex II (sensu Eukarya) -> cytoplasm, respiratory chain complex II, succinate dehydrogenase complex (ubiquinone), inner membrane
YLR304C	ACO1	tricarboxylic acid cycle, citrate metabolism, glutamate biosynthesis, propionate metabolism -> carbohydrate metabolism, amine metabolism, organic acid metabolism, energy pathways, amino acid and derivative metabolism, biosynthesis	aconitate hydratase activity -> aconitate hydratase activity	cytosol, mitochondrial matrix -> cytoplasm	CIN5, YAP6
YOR153W	PDR5	drug transport, response to drug -> transport, response to abiotic stimulus	xenobiotic-transporting ATPase activity -> xenobiotic-transporting ATPase activity	plasma membrane -> plasma membrane	YAP6
YNL231C	PDR16	phospholipid transport, sterol biosynthesis, response to drug -> transport, alcohol metabolism, response to abiotic stimulus, biosynthesis, lipid metabolism	phosphatidylinositol transporter activity -> phosphatidylinositol transporter activity	cytoplasm -> cytoplasm	HSF1, MBP1, SWI4, YAP1
Main:		biosynthesis (0.60)	pyruvate carboxylase activity (0.20)	cytoplasm (0.80)	YAP6 (0.50)
Score:		0.60	0.00	0.60	0.167
P-value:		2.167E-03 (main pathways of carbohydrate metabolism)	5.353E-01 (transporter activity)	7.999E-01 (cytosol)	1.030E-01 (YAP6)

ORF	SYMBOL	P	F	C	TF
YOR096W	RPS7A	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya) -> eukaryotic 48S initiation complex, cytoplasm, ribonucleoprotein complex	FHL1, FKH2, RAP1
YGR254W	ENO1	gluconeogenesis, glycolysis -> alcohol metabolism, carbohydrate biosynthesis, carbohydrate metabolism, energy derivation by oxidation of organic compounds, biosynthesis, catabolism	phosphopyruvate hydratase activity -> phosphopyruvate hydratase activity	phosphopyruvate hydratase complex, cytoplasm -> cytoplasm	FKH2, MSN4, PDR1, SWI5, YAP5
YNL069C	RPL16B	protein biosynthesis -> biosynthesis, protein metabolism	RNA binding, structural constituent of ribosome -> RNA binding, structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytoplasm, ribonucleoprotein complex	FHL1, GAT3, PDR1, RAP1, RGM1, YAP5
YPL090C	RPS6A	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya) -> eukaryotic 48S initiation complex, cytoplasm, ribonucleoprotein complex	FHL1, GAT3, INO4, RAP1, YAP5
YJR145C	RPS4A	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya), cytoplasm -> eukaryotic 48S initiation complex, cytoplasm, ribonucleoprotein complex	ACE2, CIN5, FHL1, INO4, MTH1, RAP1, YAP6
\|YOR213C\|	SAS5	chromatin silencing at telomere -> cell organization and biogenesis, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, transcription	acetyltransferase activity -> acetyltransferase activity	nuclear chromosome\, telomeric region, nuclear chromatin -> chromosome, nuclear chromosome	GRF10(Pho2), SUM1
YGL147C	RPL9A	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytoplasm, ribonucleoprotein complex	FHL1, MBP1, RAP1, SWI4
YML073C	RPL6A	protein biosynthesis, ribosomal large subunit assembly and maintenance -> biosynthesis, cell organization and biogenesis, protein metabolism	RNA binding, structural constituent of ribosome -> RNA binding, structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytoplasm, ribonucleoprotein complex	FHL1, GAT3, RAP1, YAP5
YGR214W	RPS0A	protein biosynthesis, ribosomal small subunit assembly and maintenance -> biosynthesis, cell organization and biogenesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya) -> eukaryotic 48S initiation complex, cytoplasm, ribonucleoprotein complex	FHL1, RAP1
YDR450W	RPS18A	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya) -> eukaryotic 48S initiation complex, cytoplasm, ribonucleoprotein complex	FHL1, GAT3, HIR2, RAP1, RGM1, YAP5
YKL152C	GPM1	gluconeogenesis, glycolysis -> alcohol metabolism, carbohydrate biosynthesis, carbohydrate metabolism, energy derivation by oxidation of organic compounds, biosynthesis, catabolism	phosphoglycerate mutase activity -> phosphoglycerate mutase activity	cytosol -> cytoplasm	GCR1, GCR2, HSF1, RAP1
YLR344W	RPL26A	protein biosynthesis -> biosynthesis, protein metabolism	RNA binding, structural constituent of ribosome -> RNA binding, structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytoplasm, ribonucleoprotein complex	FHL1, RAP1
YOR312C	RPL20B	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytoplasm, ribonucleoprotein complex	FHL1, FKH2, GAT3, RAP1
\|YDL043C\|	PRP11	spliceosome assembly -> nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism	RNA binding -> RNA binding	snRNP U2 -> nucleus, ribonucleoprotein complex	DAL81, STP1
Main:		biosynthesis (0.86)	structural constituent of ribosome (0.71)	cytoplasm (0.86)	RAP1 (0.79)
Score:		0.76	0.53	0.84	0.670
P-value:		8.659E-06 (protein biosynthesis)	3.542E-09 (structural constituent of ribosome)	2.930E-10 (cytosolic ribosome (sensu Eukarya))	8.001E-12 (FHL1)

ORF	SYMBOL	P	F	C	TF
YOL041C	NOP12	rRNA metabolism -> nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism	RNA binding -> RNA binding	nucleolus -> nucleus	GTS1, MET31
YPR010C	RPA135	transcription from Pol I promoter -> nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism	DNA-directed RNA polymerase activity -> transferase activity\, transferring phosphorus-containing groups	DNA-directed RNA polymerase I complex -> nucleus	ROX1, SIG1
YNL292W	PUS4	tRNA modification -> nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism	pseudouridylate synthase activity -> carbon-oxygen lyase activity	mitochondrion, nucleus -> cytoplasm, nucleus	RCS1
YNL112W	DBP2		RNA helicase activity -> RNA binding	bud neck -> site of polarized growth (sensu Fungi)
YKL014C	NO SYMBOL				ABF1
Main:		nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism (1.00)	RNA binding (0.50)	nucleus (0.75)	ABF1 (0.25)
Score:		1.00	0.17	0.50	0.000
P-value:		2.994E-01 (RNA metabolism)	3.258E-01 (RNA binding)	9.452E-02 (nucleolus)	3.281E-01 (SIG1)

ORF	SYMBOL	P	F	C	TF
\|YGL184C\|	STR3	methionine biosynthesis -> amine metabolism, sulfur metabolism, biosynthesis, amino acid and derivative metabolism, organic acid metabolism	cystathionine beta-lyase activity -> cystathionine beta-lyase activity	peroxisome -> cytoplasm	INO4, MET31, MET4
\|YNL019C\|	NO SYMBOL
YLR355C	ILV5	branched chain family amino acid biosynthesis, mitochondrial genome maintenance -> amine metabolism, cell organization and biogenesis, amino acid and derivative metabolism, organic acid metabolism, biosynthesis	ketol-acid reductoisomerase activity -> ketol-acid reductoisomerase activity	mitochondrion -> cytoplasm	GCN4, MET4
YPR145W	ASN1	asparagine biosynthesis -> amine metabolism, amino acid and derivative metabolism, organic acid metabolism, biosynthesis	asparagine synthase (glutamine-hydrolyzing) activity -> asparagine synthase (glutamine-hydrolyzing) activity		DAL81, GCN4, GLN3, MET4, RAP1, SUM1
YGL207W	SPT16	chromatin modeling, regulation of global transcription from Pol II promoter, RNA elongation from Pol II promoter -> cell organization and biogenesis, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, DNA metabolism	transcriptional elongation regulator activity -> transcriptional elongation regulator activity	alpha DNA polymerase\:primase complex, nuclear chromatin, transcription elongation factor complex -> nucleus, chromosome	RTG1
YNL098C	RAS2	pseudohyphal growth, sporulation (sensu Saccharomyces), adenylate cyclase activation, RAS protein signal transduction -> cell organization and biogenesis, sporulation, signal transduction	RAS small monomeric GTPase activity -> RAS small monomeric GTPase activity	plasma membrane -> plasma membrane	ACE2, SKN7
YOL092W	NO SYMBOL				MAC1
Main:		cell organization and biogenesis (0.60)	RAS small monomeric GTPase activity (0.20)	cytoplasm (0.50)	MET4 (0.50)
Score:		0.60	0.00	0.17	0.200
P-value:		1.165E-02 (amino acid biosynthesis)	1.628E+00 (enzyme activity)	4.869E+00 (cytoplasm)	1.489E-03 (MET4)

ORF	SYMBOL	P	F	C	TF
YDR309C	GIC2	axial budding, Rho protein signal transduction, establishment of cell polarity (sensu Saccharomyces) -> axial budding, small GTPase mediated signal transduction, organelle organization and biogenesis	small GTPase regulatory/interacting protein activity -> small GTPase regulatory/interacting protein activity	actin cap (sensu Saccharomyces), bud tip, shmoo tip, incipient bud site -> cell cortex, site of polarized growth (sensu Fungi), incipient bud site, cytoplasm	ASH1, HSF1, MBP1, PHD1, RLM1, SKN7, STB1, STE12, SWI4, SWI6
\|YJR006W\|	HYS2	leading strand elongation, lagging strand elongation, mutagenesis, base-excision repair, nucleotide-excision repair, postreplication repair, mismatch repair -> mutagenesis, DNA repair, postreplication repair, DNA replication and chromosome cycle, mitotic cell cycle, DNA metabolism	delta DNA polymerase activity -> delta DNA polymerase activity	delta DNA polymerase complex -> cytoplasm, nucleus	ABF1
YML027W	YOX1	negative regulation of transcription from Pol II promoter\, mitotic, regulation of mitotic cell cycle -> mitotic cell cycle, M phase, regulation of transcription, nuclear division, transcription\, DNA-dependent, regulation of cell cycle	specific transcriptional repressor activity, DNA binding -> specific transcriptional repressor activity, DNA binding	nucleus -> nucleus	MBP1, SWI4, SWI6
YDR134C	NO SYMBOL				ASH1, NRG1, SOK2, SWI4
\|YMR279C\|	NO SYMBOL				IXR1, MIG1, MTH1, RFX1, SWI4, SWI6
YMR076C	PDS5	mitotic sister chromatid cohesion, mitotic chromosome condensation -> DNA replication and chromosome cycle, M phase, mitotic cell cycle	structural molecule activity -> structural molecule activity	condensed nuclear chromosome -> chromosome, nucleus	FKH2, MBP1, SWI6
YHR110W	ERP5	secretory pathway -> secretory pathway		integral to membrane -> integral to membrane	DOT6, RGT1
Main:		mitotic cell cycle (0.60)	DNA binding (0.25)	nucleus (0.60)	SWI4 SWI6 (0.57)
Score:		0.30	0.00	0.40	0.429
P-value:		1.664E-01 (mitotic cell cycle)	2.000E+00	2.837E+00 (nucleus)	5.504E-04 (SWI6)

ORF	SYMBOL	P	F	C	TF
YMR179W	SPT21	regulation of transcription from Pol II promoter -> nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism			MBP1, STB1, SWI4, SWI6, UGA3
YML027W	YOX1	negative regulation of transcription from Pol II promoter\, mitotic, regulation of mitotic cell cycle -> transcription, cell cycle	specific transcriptional repressor activity, DNA binding -> specific transcriptional repressor activity, DNA binding	nucleus -> intracellular	MBP1, SWI4, SWI6
\|YPR185W\|	APG13	protein-vacuolar targeting, autophagy -> cell organization and biogenesis, autophagy, protein metabolism, transport	protein binding -> protein binding	extrinsic to membrane -> extrinsic to membrane	MET4, SWI6
YDL003W	MCD1	mitotic sister chromatid cohesion, mitotic chromosome condensation -> cell proliferation, cell cycle		nuclear cohesin complex -> intracellular	CIN5, MBP1, SWI6
\|YMR125W\|	STO1	mRNA splicing -> nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism	mRNA binding -> RNA binding	commitment complex, snRNA cap binding complex -> intracellular	ABF1, FZF1, HAP3, MET31, RTG1, SRD1, SUM1, YAP6, ZAP1
YGR189C	CRH1			cell wall, incipient bud site -> cell wall, intracellular	GRF10(Pho2), MBP1, RLM1, STE12, SWI4, SWI5
\|YJR030C\|	NO SYMBOL				MBP1, PHO4, RTG1, SWI6
YNL233W	BNI4	cytokinesis -> cell proliferation	protein binding -> protein binding	contractile ring (sensu Saccharomyces) -> site of polarized growth (sensu Fungi), intracellular	PHO4
YGR109C	CLB6	regulation of CDK activity, G1/S transition of mitotic cell cycle, premeiotic DNA synthesis -> cell proliferation, cell cycle, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism	cyclin-dependent protein kinase\, regulator activity -> transferase activity\, transferring phosphorus-containing groups, protein kinase regulator activity		MBP1, STB1, SWI4, SWI6
\|YMR102C\|	NO SYMBOL
YPR135W	CTF4	DNA dependent DNA replication, DNA repair -> nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, cell proliferation	DNA binding -> DNA binding	nucleus -> intracellular	BAS1, DIG1, FZF1
YNL077W	APJ1		chaperone activity -> chaperone activity		HSF1, MSN4
YNL039W	BDP1	transcription initiation from Pol III promoter -> nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism	RNA polymerase III transcription factor activity -> RNA polymerase III transcription factor activity	transcription factor TFIIIB complex -> intracellular
YMR076C	PDS5	mitotic sister chromatid cohesion, mitotic chromosome condensation -> cell proliferation, cell cycle	structural molecule activity -> structural molecule activity	condensed nuclear chromosome -> intracellular	FKH2, MBP1, SWI6
\|YJL095W\|	BCK1	protein amino acid phosphorylation, protein kinase cascade, response to nutrients, establishment of cell polarity (sensu Saccharomyces) -> phosphorus metabolism, signal transduction, response to extracellular stimulus, cell organization and biogenesis, protein metabolism, response to abiotic stimulus	MAP kinase kinase kinase activity -> transferase activity\, transferring phosphorus-containing groups	intracellular -> intracellular	YAP1
YFR027W	ECO1	sister chromatid cohesion, DNA replication, DNA repair -> nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, cell proliferation	acetyltransferase activity -> transferase activity\, transferring acyl groups	nuclear chromatin -> intracellular
YNL102W	POL1	DNA replication\, priming, DNA replication initiation, lagging strand elongation, DNA repair synthesis -> DNA metabolism, cell proliferation	alpha DNA polymerase activity -> transferase activity\, transferring phosphorus-containing groups	alpha DNA polymerase\:primase complex -> intracellular	LEU3, MBP1
\|YGR085C\|	RPL11B	protein biosynthesis, ribosomal large subunit assembly and maintenance -> biosynthesis, cell organization and biogenesis, protein metabolism	structural constituent of ribosome -> structural molecule activity	cytosolic large ribosomal subunit (sensu Eukarya) -> intracellular	FHL1, MIG1
YLR313C	SPH1	actin filament organization, polar budding, pseudohyphal growth, Rho protein signal transduction, establishment of cell polarity (sensu Saccharomyces) -> asexual reproduction, signal transduction, cell organization and biogenesis	cytoskeletal regulatory protein binding -> protein binding	polarisome, actin cap (sensu Saccharomyces), shmoo tip -> site of polarized growth (sensu Fungi), site of polarized growth (sensu Saccharomyces), intracellular	GCR1, RPH1
YML012W	ERV25	ER to Golgi transport -> transport, vesicle-mediated transport		COPII-coated vesicle -> intracellular	ABF1
YDR097C	MSH6	mismatch repair -> nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, cell proliferation	ATPase activity, ATP binding, DNA binding -> purine nucleotide binding, DNA binding, hydrolase activity\, acting on acid anhydrides	nucleus -> intracellular	DOT6, MBP1, SWI6
\|YOL006C\|	TOP1	negative regulation of recombination within rDNA repeats, DNA topological change, DNA strand elongation, chromatin assembly/disassembly, regulation of transcription from Pol II promoter, RNA elongation from Pol II promoter, mitotic chromosome condensation, nuclear migration -> cell organization and biogenesis, cell cycle, mitotic cell cycle, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism	DNA topoisomerase type I activity -> other isomerase activity	nucleus -> intracellular	REB1
\|YPL140C\|	MKK2	protein amino acid phosphorylation, signal transduction -> phosphorus metabolism, signal transduction, protein metabolism	MAP kinase kinase activity -> transferase activity\, transferring phosphorus-containing groups	intracellular -> intracellular	FKH1, FKH2
YKR077W	NO SYMBOL
YOR284W	HUA2				RFX1, YAP6
\|YLR430W\|	SEN1	35S primary transcript processing -> cell organization and biogenesis, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism	ATP dependent RNA helicase activity -> RNA binding, purine nucleotide binding, hydrolase activity\, acting on acid anhydrides	nucleolus -> intracellular	ARG80, GTS1, HAP5, RTG3, SIP4
\|YNR028W\|	CPR8		peptidyl-prolyl cis-trans isomerase activity -> cis-trans isomerase activity		ASH1, DIG1, MCM1
YOR144C	ELG1	negative regulation of DNA transposition, negative regulation of DNA recombination -> nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism			YJL206C
YDR134C	NO SYMBOL				ASH1, NRG1, SOK2, SWI4
YGL225W	VRG4	nucleotide-sugar transport, N-linked glycosylation, lipid glycosylation -> transport, biosynthesis, lipid metabolism, protein metabolism	nucleotide-sugar transporter activity -> nucleotide-sugar transporter activity	Golgi apparatus -> intracellular
YNL206C	RTT106	negative regulation of DNA transposition -> nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism			MSS11, SIP4, SUM1
YNL082W	PMS1	mismatch repair, meiosis -> DNA metabolism, cell proliferation	ATPase activity, ATP binding, DNA binding -> purine nucleotide binding, DNA binding, hydrolase activity\, acting on acid anhydrides	nuclear chromosome -> intracellular	MTH1
Main:		nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism (0.46)	DNA binding (0.19)	intracellular (0.95)	MBP1 (0.33)
Score:		0.42	0.09	0.90	0.162
P-value:		1.223E-03 (DNA replication)	2.092E+00 (isomerase activity)	5.299E-01 (chromosome)	1.349E-05 (MBP1)

ORF	SYMBOL	P	F	C	TF
YDL181W	INH1	ATP synthesis coupled proton transport -> transport		proton-transporting ATP synthase complex (sensu Eukarya) -> cytoplasm, proton-transporting ATP synthase complex, integral to membrane, inner membrane	HAP4
YLR304C	ACO1	tricarboxylic acid cycle, citrate metabolism, glutamate biosynthesis, propionate metabolism -> carbohydrate metabolism, amine metabolism, organic acid metabolism, energy pathways, amino acid and derivative metabolism, biosynthesis	aconitate hydratase activity -> carbon-oxygen lyase activity	cytosol, mitochondrial matrix -> cytoplasm	CIN5, YAP6
YNL069C	RPL16B	protein biosynthesis -> biosynthesis, protein metabolism	RNA binding, structural constituent of ribosome -> RNA binding, structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytoplasm, ribonucleoprotein complex	FHL1, GAT3, PDR1, RAP1, RGM1, YAP5
\|YPL177C\|	CUP9	copper ion homeostasis, transcription initiation from Pol II promoter -> nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, cell homeostasis, transcription	specific RNA polymerase II transcription factor activity -> specific RNA polymerase II transcription factor activity	nucleus -> nucleus	BAS1, CIN5, MAC1, PHD1, SWI4, YAP6
\|YJL079C\|	PRY1			nuclear membrane, endoplasmic reticulum -> nucleus, cytoplasm, endomembrane system	NDD1, PHD1, RAP1
YDL137W	ARF2	ER to Golgi transport, intra-Golgi transport -> transport, vesicle-mediated transport	ARF small monomeric GTPase activity -> purine nucleotide binding, hydrolase activity\, acting on acid anhydrides	Golgi vesicle, cytosol -> cytoplasm, Golgi apparatus	MSS11, REB1, RGT1, SIG1, SKN7, SOK2
YMR143W	RPS16A	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya) -> eukaryotic 48S initiation complex, cytoplasm, ribonucleoprotein complex	FHL1, GAT3, RAP1, RGM1, YAP5
YPR035W	GLN1	nitrogen metabolism, glutamine biosynthesis -> nitrogen metabolism, amine metabolism, amino acid and derivative metabolism, organic acid metabolism, biosynthesis	glutamate-ammonia ligase activity -> ligase activity\, forming carbon-nitrogen bonds	cytoplasm -> cytoplasm	CIN5, DAL81, FKH1, FKH2, GLN3, HSF1, INO4, MSN1, REB1, SWI4
\|YNL040W\|	NO SYMBOL				FZF1, GCR2, RTG3, YAP7
\|YKL198C\|	PTK1	polyamine transport -> transport	protein kinase activity -> transferase activity\, transferring phosphorus-containing groups		INO2
YDR377W	ATP17	ATP synthesis coupled proton transport -> transport	hydrogen-transporting ATP synthase activity -> cation transporter activity	proton-transporting ATP synthase complex\, coupling factor F(o) (sensu Eukarya) -> cytoplasm, proton-transporting ATP synthase complex, integral to membrane, inner membrane	ARO80, HAP2, HAP3, HAP4, RPH1
YFR033C	QCR6	aerobic respiration, oxidative phosphorylation\, ubiquinone to cytochrome c -> energy pathways, electron transport, phosphorus metabolism	ubiquinol-cytochrome c reductase activity -> oxidoreductase activity\, acting on diphenols and related substances as donors, primary active transporter activity, cation transporter activity	mitochondrion, respiratory chain complex III (sensu Eukarya) -> cytoplasm, respiratory chain complex III, inner membrane	HAP4, MBP1
YDL140C	RPO21	transcription from Pol II promoter -> nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism	DNA-directed RNA polymerase activity -> transferase activity\, transferring phosphorus-containing groups	DNA-directed RNA polymerase II\, core complex -> nucleus	REB1
Main:		biosynthesis (0.36)	structural constituent of ribosome (0.20)	cytoplasm (0.82)	REB1 HAP4 RAP1 CIN5 (0.23)
Score:		0.25	0.07	0.71	0.167
P-value:		4.375E-02 (ATP synthesis coupled proton transport)	1.008E-01 (hydrogen ion transporter activity)	3.537E-02 (proton-transporting ATP synthase complex)	2.498E-02 (HAP4)

ORF	SYMBOL	P	F	C	TF
\|YNL311C\|	NO SYMBOL				GCN4, RAP1
\|YMR224C\|	MRE11	DNA repair, double-strand break repair via nonhomologous end-joining, meiotic DNA double-strand break formation, meiotic DNA double-strand break processing, double-strand break repair via break-induced replication -> DNA metabolism, cell proliferation, catabolism	endonuclease activity, 3'-5' exonuclease activity, protein binding -> nuclease activity, protein binding	nucleus -> nucleus	RAP1
YLR452C	SST2	signal transduction, adaptation to pheromone during conjugation with cellular fusion -> signal transduction, conjugation, perception of external stimulus, sexual reproduction, response to abiotic stimulus	GTPase activator activity -> GTPase activator activity	plasma membrane -> membrane	DIG1, FHL1, RAP1, STE12
YNL069C	RPL16B	protein biosynthesis -> biosynthesis, protein metabolism	RNA binding, structural constituent of ribosome -> RNA binding, structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytoplasm, ribonucleoprotein complex	FHL1, GAT3, PDR1, RAP1, RGM1, YAP5
YJR145C	RPS4A	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya), cytoplasm -> eukaryotic 48S initiation complex, cytoplasm, ribonucleoprotein complex	ACE2, CIN5, FHL1, INO4, MTH1, RAP1, YAP6
YGL030W	RPL30	protein biosynthesis, rRNA processing, mRNA splicing, regulation of translation -> cell organization and biogenesis, biosynthesis, transcription, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya), cytoplasm -> cytoplasm, ribonucleoprotein complex	FHL1, GAT3, RAP1, SFP1
\|YGL196W\|	NO SYMBOL
YDR450W	RPS18A	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya) -> eukaryotic 48S initiation complex, cytoplasm, ribonucleoprotein complex	FHL1, GAT3, HIR2, RAP1, RGM1, YAP5
\|YJL217W\|	NO SYMBOL				CIN5, MAC1, PHD1, SWI5, YAP6
YMR194W	RPL36A	protein biosynthesis -> biosynthesis, protein metabolism	RNA binding, structural constituent of ribosome -> RNA binding, structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytoplasm, ribonucleoprotein complex	ARG80, ARO80, BAS1, CUP9, FHL1, HAL9, HAP4, HAP5, HMS1, MET31, NRG1, RAP1, RCS1, RME1, STP2
YLR441C	RPS1A	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya) -> eukaryotic 48S initiation complex, cytoplasm, ribonucleoprotein complex	FHL1, GAT3, RAP1, YAP5
YPR080W	TEF1	translational elongation -> biosynthesis, protein metabolism	translation elongation factor activity -> translation elongation factor activity	ribosome -> cytoplasm, ribonucleoprotein complex	FHL1, PDR1, RAP1, YAP5
YOR312C	RPL20B	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytoplasm, ribonucleoprotein complex	FHL1, FKH2, GAT3, RAP1
YLR249W	YEF3	translational elongation -> biosynthesis, protein metabolism	translation elongation factor activity -> translation elongation factor activity	ribosome -> cytoplasm, ribonucleoprotein complex	INO2, INO4
\|YKR092C\|	SRP40	nucleocytoplasmic transport -> transport	chaperone activity -> chaperone activity	nucleolus -> nucleus	CUP9, MET4, RAP1
YKL006W	RPL14A	protein biosynthesis -> biosynthesis, protein metabolism	RNA binding, structural constituent of ribosome -> RNA binding, structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytoplasm, ribonucleoprotein complex	FHL1, GAT3, GRF10(Pho2), GTS1, RAP1
\|YPR161C\|	SGV1	transcription, protein amino acid phosphorylation -> nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, phosphorus metabolism, protein metabolism	cyclin-dependent protein kinase activity -> phosphotransferase activity\, alcohol group as acceptor	nucleus -> nucleus	RAP1
\|YOR213C\|	SAS5	chromatin silencing at telomere -> cell organization and biogenesis, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, transcription	acetyltransferase activity -> transferase activity\, transferring groups other than amino-acyl groups	nuclear chromosome\, telomeric region, nuclear chromatin -> chromosome, nuclear chromosome	GRF10(Pho2), SUM1
YOR369C	RPS12	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya) -> eukaryotic 48S initiation complex, cytoplasm, ribonucleoprotein complex	ARG80, FHL1, FKH2, LEU3, NDD1, PDR1, RME1, SMP1, YAP6
YMR013C	SEC59	protein-ER targeting, protein amino acid glycosylation -> cell organization and biogenesis, biosynthesis, protein modification, protein metabolism, transport	dolichol kinase activity -> phosphotransferase activity\, alcohol group as acceptor	membrane -> membrane	FHL1, NDD1, RAP1, RLM1, RME1
YGL115W	SNF4	regulation of transcription from Pol II promoter, peroxisome organization and biogenesis -> cell organization and biogenesis, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism	protein kinase activator activity -> protein kinase activator activity	plasma membrane, nucleus, cytoplasm -> membrane, nucleus, cytoplasm	BAS1, CAD1, MAC1, NRG1, PDR1, RAP1, SMP1, YAP5
YOL120C	RPL18A	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytoplasm, ribonucleoprotein complex	FHL1, MAL13, RAP1, YAP5
YLR344W	RPL26A	protein biosynthesis -> biosynthesis, protein metabolism	RNA binding, structural constituent of ribosome -> RNA binding, structural constituent of ribosome	cytosolic large ribosomal subunit (sensu Eukarya) -> cytoplasm, ribonucleoprotein complex	FHL1, RAP1
Main:		protein metabolism (0.75)	structural constituent of ribosome (0.55)	cytoplasm (0.70)	RAP1 (0.82)
Score:		0.59	0.30	0.53	0.745
P-value:		3.851E-07 (protein biosynthesis)	3.734E-07 (structural constituent of ribosome)	1.306E-08 (cytosolic ribosome (sensu Eukarya))	4.765E-17 (RAP1)

ORF	SYMBOL	P	F	C	TF
YLR333C	RPS25B	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya) -> eukaryotic 48S initiation complex, cytoplasm, ribonucleoprotein complex	FHL1, RAP1
YOR315W	NO SYMBOL				ACE2, CIN5, CUP9, FKH2, IXR1, MCM1, NDD1, NRG1, RLM1, ROX1, SKN7, SUM1, SWI4, SWI6, YAP1, YAP6
YDL140C	RPO21	transcription from Pol II promoter -> nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism	DNA-directed RNA polymerase activity -> nucleotidyltransferase activity	DNA-directed RNA polymerase II\, core complex -> nucleus	REB1
YNR053C	NOG2	mRNA splicing -> nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism	GTPase activity -> guanyl nucleotide binding, hydrolase activity\, acting on acid anhydrides\, in phosphorus-containing anhydrides	nucleus, nucleolus, nucleoplasm -> nucleus, nucleoplasm	ABF1, AZF1
YLR328W	NMA1	nicotinamide adenine dinucleotide metabolism -> coenzymes and prosthetic group metabolism, vitamin metabolism	nicotinamide-nucleotide adenylyltransferase activity -> nucleotidyltransferase activity		CIN5, MSN1, ROX1
\|YOR066W\|	NO SYMBOL				MBP1, MCM1
\|YPL128C\|	TBF1	loss of chromatin silencing -> cell organization and biogenesis, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, transcription	DNA binding, transcription factor activity -> DNA binding, transcription factor activity	nuclear chromosome\, telomeric region, nuclear chromosome, nucleus -> chromosome, nucleus
YML058W	SML1	response to DNA damage, mitochondrion organization and biogenesis -> response to biotic stimulus, cell organization and biogenesis	enzyme inhibitor activity -> enzyme inhibitor activity		NDD1, RFX1, SWI6
YJL159W	HSP150	cell wall organization and biogenesis -> cell organization and biogenesis	structural constituent of cell wall -> structural constituent of cell wall	cell wall -> cell wall	ACE2, HIR2, MCM1, RLM1, SWI5
Main:		cell organization and biogenesis (0.43)	nucleotidyltransferase activity (0.29)	nucleus (0.60)	MCM1 (0.38)
Score:		0.29	0.05	0.30	0.179
P-value:		2.826E+00 (transcription\, DNA-dependent)	8.582E-02 (nucleotidyltransferase activity)	7.322E-01 (nucleoplasm)	7.098E-02 (MCM1)

ORF	SYMBOL	P	F	C	TF
\|YIL066C\|	RNR3	DNA replication -> cell proliferation, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism	ribonucleoside-diphosphate reductase activity -> ribonucleoside-diphosphate reductase activity	cytoplasm -> cytoplasm	RFX1, STB1
YGR109C	CLB6	regulation of CDK activity, G1/S transition of mitotic cell cycle, premeiotic DNA synthesis -> cell proliferation, cell cycle, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism	cyclin-dependent protein kinase\, regulator activity -> cyclin-dependent protein kinase\, regulator activity		MBP1, STB1, SWI4, SWI6
YJR154W	NO SYMBOL				CIN5, GCN4, RIM101
YHR110W	ERP5	secretory pathway -> transport		integral to membrane -> integral to membrane	DOT6, RGT1
YJL181W	NO SYMBOL
YPR185W	APG13	protein-vacuolar targeting, autophagy -> cell organization and biogenesis, autophagy, protein metabolism, transport	protein binding -> protein binding	extrinsic to membrane -> extrinsic to membrane	MET4, SWI6
Main:		cell proliferation (0.50)	cyclin-dependent protein kinase\, regulator activity (0.33)	extrinsic to membrane (0.33)	SWI6 STB1 (0.40)
Score:		0.33	0.00	0.00	0.200
P-value:		1.640E-01 (DNA replication)	2.725E+00 (enzyme activity)	1.666E+00 (membrane)	2.568E-02 (STB1)

ORF	SYMBOL	P	F	C	TF
\|YOR033C\|	EXO1	mismatch repair -> DNA replication and chromosome cycle, DNA repair, mitotic cell cycle, DNA metabolism	exonuclease activity, flap endonuclease activity, 5'-3' exonuclease activity -> DNA binding, nuclease activity	nucleus -> nucleus	RGT1
YFR031C	SMC2	mitotic chromosome condensation, mitotic chromosome segregation -> DNA replication and chromosome cycle, M phase of mitotic cell cycle, M phase	DNA secondary structure binding, AT DNA binding, double-stranded DNA binding, ATPase activity -> DNA binding, double-stranded DNA binding, purine nucleotide binding, hydrolase activity\, acting on acid anhydrides	nuclear condensin complex -> chromosome, nucleus	INO2, MET4
YMR279C	NO SYMBOL				IXR1, MIG1, MTH1, RFX1, SWI4, SWI6
YNL102W	POL1	DNA replication\, priming, DNA replication initiation, lagging strand elongation, DNA repair synthesis -> DNA replication and chromosome cycle, mitotic recombination, mitotic cell cycle, DNA metabolism, DNA repair	alpha DNA polymerase activity -> transferase activity\, transferring phosphorus-containing groups	alpha DNA polymerase\:primase complex -> nucleus	LEU3, MBP1
\|YDR093W\|	DNF2	intracellular protein transport -> intracellular protein transport	phospholipid-translocating ATPase activity -> phospholipid binding, purine nucleotide binding, primary active transporter activity, cation transporter activity, hydrolase activity\, acting on acid anhydrides	plasma membrane -> plasma membrane	GTS1
YDR279W	RNH202				GCR2, MBP1, RIM101, RLM1, SWI6, THI2
YJR001W	AVT1	neutral amino acid transport -> amine/polyamine transport, carboxylic acid transport	neutral amino acid transporter activity -> carboxylic acid transporter activity	vacuole -> cytoplasm	CRZ1, GAT3, MATa1
Main:		DNA replication and chromosome cycle (0.60)	DNA binding (0.40)	nucleus (0.60)	MBP1 SWI6 (0.29)
Score:		0.30	0.20	0.30	0.095
P-value:		1.005E-01 (DNA replication and chromosome cycle)	6.142E-01 (ATPase activity)	2.364E+00 (nucleus)	3.407E-01 (SWI6)

ORF	SYMBOL	P	F	C	TF
YOR273C	TPO4	polyamine transport -> transport	spermine transporter activity, spermidine transporter activity -> spermine transporter activity, spermidine transporter activity	plasma membrane, vacuolar membrane -> plasma membrane, cytoplasm	ARO80, BAS1, FZF1, HIR1, IME4, NRG1, PDR1, PHO4, SFP1, SKN7, STP1
YLR304C	ACO1	tricarboxylic acid cycle, citrate metabolism, glutamate biosynthesis, propionate metabolism -> carbohydrate metabolism, amine metabolism, organic acid metabolism, energy pathways, amino acid and derivative metabolism, biosynthesis	aconitate hydratase activity -> aconitate hydratase activity	cytosol, mitochondrial matrix -> cytoplasm	CIN5, YAP6
YKR042W	UTH1	mitochondrion organization and biogenesis -> cell organization and biogenesis		cell wall, mitochondrial outer membrane -> cell wall, cytoplasm, outer membrane	ACE2, ASH1, DAL81, FKH2, HSF1, MCM1, NDD1, SKN7, STE12, SWI4
\|YFR022W\|	NO SYMBOL
YML116W	ATR1	multidrug transport -> transport, response to abiotic stimulus	multidrug efflux pump activity -> multidrug efflux pump activity	plasma membrane -> plasma membrane	CAD1, CIN5, FKH2, HSF1, PHD1, YAP1, YAP6
YJL082W	IML2
YMR291W	NO SYMBOL				RAP1
\|YNL289W\|	PCL1	cell cycle -> cell proliferation	cyclin-dependent protein kinase\, regulator activity -> cyclin-dependent protein kinase\, regulator activity	cyclin-dependent protein kinase holoenzyme complex -> cyclin-dependent protein kinase holoenzyme complex	ASH1, MBP1, MCM1, STB1, STE12, SWI4, SWI6
YKL163W	PIR3	cell wall organization and biogenesis -> cell organization and biogenesis	structural constituent of cell wall -> structural constituent of cell wall	cell wall -> cell wall	MCM1, SMP1, SWI5
\|YOL011W\|	PLB3	phosphoinositide metabolism, phosphatidylserine catabolism -> catabolism, lipid metabolism	lysophospholipase activity -> lysophospholipase activity	extracellular space, plasma membrane -> extracellular space, plasma membrane	SWI4
YML058W	SML1	response to DNA damage, mitochondrion organization and biogenesis -> response to biotic stimulus, cell organization and biogenesis	enzyme inhibitor activity -> enzyme inhibitor activity		NDD1, RFX1, SWI6
Main:		cell organization and biogenesis (0.38)	structural constituent of cell wall (0.14)	cytoplasm (0.43)	SWI4 MCM1 (0.33)
Score:		0.14	0.00	0.33	0.278
P-value:		3.512E-01 (mitochondrion organization and biogenesis)	3.385E-01 (enzyme regulator activity)	2.965E-01 (plasma membrane)	1.558E-01 (ASH1)

ORF	SYMBOL	P	F	C	TF
YML026C	RPS18B	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya) -> eukaryotic 48S initiation complex, cytoplasm, ribonucleoprotein complex	FHL1, GAT3, RAP1, RGM1, SWI4, YAP5
YLR441C	RPS1A	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya) -> eukaryotic 48S initiation complex, cytoplasm, ribonucleoprotein complex	FHL1, GAT3, RAP1, YAP5
YGR254W	ENO1	gluconeogenesis, glycolysis -> alcohol metabolism, carbohydrate biosynthesis, carbohydrate metabolism, energy derivation by oxidation of organic compounds, biosynthesis, catabolism	phosphopyruvate hydratase activity -> phosphopyruvate hydratase activity	phosphopyruvate hydratase complex, cytoplasm -> cytoplasm	FKH2, MSN4, PDR1, SWI5, YAP5
YPR080W	TEF1	translational elongation -> biosynthesis, protein metabolism	translation elongation factor activity -> translation elongation factor activity	ribosome -> cytoplasm, ribonucleoprotein complex	FHL1, PDR1, RAP1, YAP5
YNL096C	RPS7B	protein biosynthesis -> biosynthesis, protein metabolism	structural constituent of ribosome -> structural constituent of ribosome	cytosolic small ribosomal subunit (sensu Eukarya) -> eukaryotic 48S initiation complex, cytoplasm, ribonucleoprotein complex	FHL1, GAT3, RAP1, SFP1
\|YOR213C\|	SAS5	chromatin silencing at telomere -> cell organization and biogenesis, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, transcription	acetyltransferase activity -> acetyltransferase activity	nuclear chromosome\, telomeric region, nuclear chromatin -> chromosome, nuclear chromosome	GRF10(Pho2), SUM1
Main:		biosynthesis (0.83)	structural constituent of ribosome (0.50)	cytoplasm (0.83)	FHL1 RAP1 YAP5 (0.67)
Score:		0.67	0.20	0.67	0.600
P-value:		1.770E-02 (biosynthesis)	2.066E-02 (structural constituent of ribosome)	1.614E-03 (cytosolic small ribosomal subunit (sensu Eukarya))	1.154E-05 (YAP5)

ORF	SYMBOL	P	F	C	TF
YHR184W	SSP1	spore wall assembly (sensu Saccharomyces), protein complex assembly -> protein metabolism, sporulation		prospore membrane -> prospore	SUM1
YOR338W	NO SYMBOL				RAP1
YOL091W	SPO21	spore wall assembly (sensu Saccharomyces), meiosis -> cell proliferation, sporulation	structural molecule activity -> structural molecule activity	spindle pole body -> cytoplasm	HAP5, SUM1
YOR339C	UBC11	protein polyubiquitination, protein monoubiquitination -> catabolism, protein metabolism	ubiquitin conjugating enzyme activity -> ubiquitin conjugating enzyme activity	cytoplasm -> cytoplasm	HAP2, IXR1
\|YGL253W\|	HXK2	fructose metabolism -> alcohol metabolism, carbohydrate metabolism	hexokinase activity -> hexokinase activity	nucleus, cytosol -> nucleus, cytoplasm	ABF1, CIN5, HSF1, SWI4
\|YJR007W\|	SUI2	translational initiation -> biosynthesis, protein metabolism	translation initiation factor activity -> translation initiation factor activity	ribosome, cytoplasm -> cytoplasm, ribonucleoprotein complex	GLN3, HAP3, HIR1, RCS1
YFR023W	PES4	DNA dependent DNA replication -> cell proliferation, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism			DIG1, FKH1, FKH2, GLN3, HAP3, MCM1, MSN2, RIM101, RLM1, RTG3, STE12, SUM1, THI2, YAP1
Main:		protein metabolism (0.50)	ubiquitin conjugating enzyme activity (0.25)	cytoplasm (0.80)	SUM1 (0.43)
Score:		0.33	0.00	0.60	0.190
P-value:		1.686E-02 (spore wall assembly (sensu Saccharomyces))	2.849E+00 (enzyme activity)	3.294E+00 (cytoplasm)	4.371E-03 (SUM1)

ORF	SYMBOL	P	F	C	TF
YMR083W	ADH3	fermentation -> fermentation	alcohol dehydrogenase activity -> alcohol dehydrogenase activity	mitochondrial matrix, soluble fraction -> mitochondrial matrix, soluble fraction	RAP1
\|YOR389W\|	NO SYMBOL				MCM1, YJL206C
YHL035C	NO SYMBOL				YFL044C
YMR253C	NO SYMBOL				MCM1
YMR088C	NO SYMBOL
\|YHR209W\|	NO SYMBOL				LEU3
YOR381W	FRE3	iron-siderochrome transport, iron ion homeostasis -> iron-siderochrome transport, iron ion homeostasis	ferric-chelate reductase activity -> ferric-chelate reductase activity	plasma membrane, integral to membrane -> plasma membrane, integral to membrane	CIN5, PDR1, YAP6
YKL167C	MRP49	protein biosynthesis -> protein biosynthesis	structural constituent of ribosome -> structural constituent of ribosome	mitochondrial large ribosomal subunit -> mitochondrial matrix, large ribosomal subunit, organellar ribosome	ABF1, IME4, IXR1
Main:		iron ion homeostasis (0.33)	ferric-chelate reductase activity (0.33)	mitochondrial matrix (0.67)	MCM1 (0.29)
Score:		0.00	0.00	0.33	0.048
P-value:		3.993E+00 (metabolism)	4.865E-01 (oxidoreductase activity)	2.572E-01 (mitochondrial matrix)	3.069E-01 (MCM1)

ORF	SYMBOL	P	F	C	TF
YKL078W	DHR2	ribosome biogenesis -> cytoplasm organization and biogenesis	RNA helicase activity -> RNA binding	nucleolus -> nucleus	ABF1
YNL292W	PUS4	tRNA modification -> RNA metabolism	pseudouridylate synthase activity -> carbon-oxygen lyase activity	mitochondrion, nucleus -> cytoplasm, nucleus	RCS1
\|YGR283C\|	NO SYMBOL				ACE2, RAP1, SMP1
YGR187C	HGH1				ABF1, HAP3, HIR1, RCS1, RTG1
YKL014C	NO SYMBOL				ABF1
YOL041C	NOP12	rRNA metabolism -> RNA metabolism	RNA binding -> RNA binding	nucleolus -> nucleus	GTS1, MET31
YJL069C	UTP18				ABF1
Main:		RNA metabolism (0.67)	RNA binding (0.67)	nucleus (1.00)	ABF1 (0.57)
Score:		0.33	0.33	1.00	0.333
P-value:		5.684E-01 (RNA metabolism)	6.158E-01 (RNA binding)	1.881E-01 (nucleolus)	6.557E-03 (ABF1)

ORF	SYMBOL	P	F	C	TF
\|YNL042W\|	BOP3				DAL82
YGR280C	PXR1	35S primary transcript processing, snRNA processing -> cell organization and biogenesis, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism	RNA binding -> RNA binding	nucleolus -> nucleus
YDL140C	RPO21	transcription from Pol II promoter -> nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism	DNA-directed RNA polymerase activity -> transferase activity\, transferring phosphorus-containing groups	DNA-directed RNA polymerase II\, core complex -> nucleus	REB1
YML093W	UTP14	processing of 20S pre-rRNA -> cell organization and biogenesis, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism	snoRNA binding -> RNA binding	small nucleolar ribonucleoprotein complex -> nucleus, ribonucleoprotein complex
YOL130W	ALR1	di-\, tri-valent inorganic cation transport, magnesium ion transport -> transport	di-\, tri-valent inorganic cation transporter activity -> cation transporter activity	plasma membrane -> plasma membrane
\|YLR328W\|	NMA1	nicotinamide adenine dinucleotide metabolism -> coenzymes and prosthetic group metabolism, vitamin metabolism	nicotinamide-nucleotide adenylyltransferase activity -> transferase activity\, transferring phosphorus-containing groups		CIN5, MSN1, ROX1
YDL088C	ASM4	protein-nucleus import\, docking, mRNA-nucleus export, rRNA-nucleus export, snRNA-nucleus export, NLS-bearing substrate-nucleus import, snRNP protein-nucleus import, mRNA-binding (hnRNP) protein-nucleus import, ribosomal protein-nucleus import, protein-nucleus export, nuclear pore organization and biogenesis -> intracellular transport, nuclear organization and biogenesis, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, protein metabolism, transport	structural molecule activity -> structural molecule activity	nuclear pore -> nucleus, integral to membrane, endomembrane system
YMR042W	ARG80	positive regulation of transcription from Pol II promoter, arginine metabolism -> amine metabolism, nitrogen metabolism, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, amino acid and derivative metabolism, organic acid metabolism	DNA binding, specific RNA polymerase II transcription factor activity -> DNA binding, specific RNA polymerase II transcription factor activity	nucleus -> nucleus	RME1
Main:		nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism (0.71)	RNA binding (0.29)	nucleus (0.83)	DAL82 (0.25)
Score:		0.52	0.10	0.67	0.000
P-value:		1.624E-01 (transcription\, DNA-dependent)	7.594E-02 (nucleotidyltransferase activity)	2.848E-01 (nucleolus)	2.035E-01 (MSN1)