Table 7 False positives in Oncogenesis: missing annotations

 

This table shows genes classified but not annotated with the biological process oncogenesis (e.g. false positives for oncogenesis), where information could be found in the literature confirming that the classification was correct and thus represented knowledge that was missed out during annotation (missing annotation).

 

Symbol

(Accession number)

Gene name     

Molecular function

Comment

Reference (PMID)

 

CCNG1

(R45687)

 

Cyclin G1

 

CDK  kinase regulator

 

p53 target

 

11327114

CDKN1C

(R81336)

cyclin-dependent kinase inhibitor 1C

 

cyclin-dependent protein kinase inhibitor

tumor suppressor

7729684

 

CAT

(W89002)

catalase

 

oxidoreductase

tumor progression

8513880, 11597785

ALDH3A2

(H63779)

aldehyde dehydrogenase 10

 

aldehyde dehydrogenase

tumor progression

92393980

 

ADD3

(AA054129)

adducin 3 (gamma)

membrane-cytoskeleton-associated protein

tumor progression

9607561

 

TFDP2

(W46792)

transcription factor Dp-2 (E2F dimerization partner 2)

transcription co-factor

cell cycle regulation

7784053

 

ATRX

(N22858)

alpha thalassemia/mental retardation syndrome

DNA helicase

transcription & DNA repair

10362365, 10630641

 

EPS15

(N78949)

epidermal growth factor receptor pathway substrate 15

kinase substrate

growth regulation

93361014

 

EGR1

(H27557)

early growth response 1

 

transcription factor

 tumor suppressor

9109500

 

NR4A2

(N22386)

nuclear receptor subfam 4, group A, m2 (Nurr1, Not)

ligand-dependent nuclear receptor

proto-oncogene

9592180

 

NR4A3

(W42606)

nuclear receptor subfam 4, group A, m 3 (Nor1)

ligand-dependent nuclear receptor

proto-oncogene

9592180

 

COPEB

(AA055585)

core promoter element binding protein

 

transcription factor

proto-oncogene

9268646